OMA1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 1575 Sequence: atgagcttca tctgtggatt gcagtctgct gctagaaacc atgttttctt ccgatttaat tcactgtcta actggagaaa atgtaacaca ttagcatcca cctcacgggg ctgtcatcaa gtacaagtta accatatagt aaataagtat cagggactgg gagtaaatca gtgtgacagg tggagttttc tgcctggaaa ctttcatttt tatagtactt ttaacaacaa aagaacagga ggcctctcaa gtaccaaaag taaggaaatt tggaggatta ccagcaaatg tactgtatgg aatgatgctt tttcaagaca gctgctaata aaagaagtta cagcagtccc tagtctgtca gtattgcatc ctctaagccc tgcttccata agagctatta ggaatttcca tacttctcca cggtttcaag ctgctccggt tcctctcttg ttgatgattc ttaaaccagt acagaagtta tttgcaatca ttgtaggcag gggcataagg aaatggtggc aggcacttcc tcctaacaag aaggaagtag ttaaagaaaa tataaggaag aataaatgga agctattcct tggtttgagt agttttggat tgctctttgt ggtgttttat tttactcacc tggaagtaag tccaatcaca ggaaggagca agctactatt attggggaaa gaacagttca gacttttatc ggaactggaa tatgaagcat ggatggaaga atttaaaaat gatatgctaa ctgagaaaga tgcccgatac ctggctgtta aagaagtgct ttgtcatcta attgaatgca ataaagatgt tccagggatc tctcagatca attgggttat tcatgtggtt gattccccaa ttattaatgc cttcgtgctt ccaaatggac aaatgtttgt tttcactgga tttttaaata gtgtaaccga tattcatcaa ctttctttcc ttctgggcca tgaaatagca catgcagtac ttgggcatgc tgcagaaaag gctggcatgg ttcatttgtt ggatttccta ggtatgattt tcctcacaat gatttgggcc atttgtcctc gagatagctt ggcacttttg tgccagtgga tacagtctaa attgcaggag tatatgttta atagaccata cagcagaaaa ttggaggccg aagctgacaa aattggacta ctgcttgctg caaaggcttg tgcagacata agagccagtt cagtgttttg gcagcaaatg gagttcgttg atagcctgca tggccaaccc aagatgccag aatggttatc tacacaccct tctcatggca atcgagttga gtacttggat agacttatac ctcaggctct caaaattaga gagatgtgta attgtccacc actgtctaat ccagaccctc gattactatt caaactcagc acgaagcatt ttcttgaaga atcagagaaa gaagacctaa atatcacgaa gaaacagaaa atggatactc ttcctattca aaaacaggag caaataccat taacatacat agttgagaaa agaacgggca Protein function: Metalloprotease that is part of the quality control system in the inner membrane of mitochondria (PubMed:20038677, PubMed:25605331, PubMed:32132706, PubMed:32132707). Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1 (PubMed:20038677, PubMed:25275009, PubMed:32132706, PubMed:32132707). Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion (PubMed:20038677, PubMed:25275009). Also acts as a regulator of apoptosis: upon BAK and BAX aggregation, mediates cleavage of OPA1, leading to the remodeling of mitochondrial cristae and allowing the release of cytochrome c from mitochondrial cristae (PubMed:25275009). In depolarized mitochondria, may also act as a backup protease for PINK1 by mediating PINK1 cleavage and promoting its subsequent degradation by the proteasome (PubMed:30733118). May also cleave UQCC3 in response to mitochondrial depolarization (PubMed:25605331). Also acts as an activator of the integrated stress response (ISR): in response to mitochondrial stress, mediates cleavage of DELE1 to generate the processed form of DELE1 (S- DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR (PubMed:32132706, PubMed:32132707). Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. Binds cardiolipin, possibly regulating its protein turnover. Required for the stability of the respiratory supercomplexes. [The UniProt Consortium]