OBFC2B (Vector pUC, Accession No. BC001079)

Length: 636 Sequence: atgacgacgg agacctttgt gaaggatatc aagcctgggc tcaagaatct gaaccttatc ttcattgtgc tggagacagg ccgagtgacc aagacaaagg acgggcatga ggttcggacc tgcaaagtgg cggacaaaac aggcagcatc aatatctctg tctgggacga tgttggcaat ctgatccagc ctggggacat tatccggctc accaaagggt acgcttcagt tttcaaaggt tgtctgacac tatatactgg ccgtgggggt gatctgcaga agattggaga attctgtatg gtttattctg aggttcctaa cttcagtgag ccaaacccag agtacagcac ccagcaggca cccaacaagg cggtgcagaa cgacagcaac ccttcagctt cccagcctac cactggaccc tctgctgcct ctccagcctc tgagaaccag aatgggaatg gactgagtgc cccaccaggt cccggtggtg gcccacatcc ccctcatact ccctcccacc cacccagcac ccgaatcact cgaagccagc ccaaccacac acctgcaggc ccgcctggcc cttccagcaa ccctgttagt aacggcaaag aaacccggag gagcagcaag Protein function: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM- dependent signaling pathways. [The UniProt Consortium]