NUDT3 (Vector pENTR223.1, Accession No. BC007727)

Length: 519 Sequence: atgatgaagc tcaagtcgaa ccagacccgc acctacgacg gcgacggcta caagaagcgg gccgcatgcc tgtgtttccg cagcgagagc gaggaggagg tgctactcgt gagcagtagt cgccatccag acagatggat tgtccctgga ggaggcatgg agcccgagga ggagccaagt gtggcagcag ttcgtgaagt ctgtgaggag gctggagtaa aagggacatt gggaagatta gttggaattt ttgagaacca ggagaggaag cacaggacgt atgtctatgt gctcattgtc actgaagtgc tggaagactg ggaagattca gttaacattg gaaggaagag ggaatggttt aaaatagaag acgccataaa agtgctgcag tatcacaaac ccgtgcaggc atcatatttt gaaacattga ggcaaggcta ctcagccaac aatggcaccc cagtcgtggc caccacatac tcggtttctg ctcagagctc gatgtcaggc Protein function: Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. [The UniProt Consortium]