NUDT16L1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pU

Length: 636 Sequence: atgtcgacgg cggcggttcc ggagctgaag cagatcagcc gggtggaggc gatgcgccta gggccgggct ggagccactc gtgccacgcc atgctgtacg ccgccaaccc tgggcagctc ttcggccgca tccccatgcg cttctcggtg ctgatgcaga tgcgtttcga cgggctgctg ggcttccccg ggggcttcgt ggaccggcgc ttctggtcgc tggaggacgg cctgaaccgg gtgctgggcc tgggcctggg ctgcctgcgc ctcaccgagg ccgactacct gagctcgcac ctgaccgagg gcccacaccg cgtcgtggcg cacctgtacg cgcggcagct gacgctggag cagctgcacg ccgtggagat cagcgcggtg cactcgcgcg accacggcct ggaggtgctg ggcctcgtgc gggtcccgct gtacacccag aaggaccgag tcggaggctt ccccaacttc ctgagcaacg ccttcgtgag cacggctaag tgccagctcc tctttgccct caaggtgctc aacatgatgc ccgaggagaa gctggttgag gccctggctg cagccaccga gaagcagaag aaggccctgg agaagttgct cccggcctcc Protein function: Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299). [The UniProt Consortium]