NSMCE4A (Vector pUC, Accession No. BC005212)

Length: 951 Sequence: atgtctgggg acagcagcgg ccgcgggcca gagggccggg gccggggccg cgacccgcat cgggatcgca cccgctcccg ctcccgctcg cggtcccctt tgtcgcccag gtcccgccgc ggctctgcgc gggagcgcag agaggcccca gagcgcccga gcctggagga cacagagccg tcggattccg gggacgagat gatggacccg gccagcttgg aggcggaggc cgaccaaggc ctgtgccgcc agatccgcca tcagtaccgg gcgctcatca actccgtcca acaaaaccgt gaggacatac tgaatgccgg tgacaaatta acagaggtcc ttgaagaggc taacactctg tttaatgaag tgtcccgagc aagagaagca gtcctggatg cccactttct tgttttggct tcagatttgg gcaaagagaa agcaaagcag ctgcgctcag acctgagctc ctttgacatg ttaagatatg ttgaaactct actcacacat atgggtgtaa atccgctaga agctgaagaa ctcatccgtg atgaagatag tcctgatttt gaattcatag tctatgactc ctggaagata acaggcagaa cagcagaaaa cacctttaat aaaacccata cattccactt tctgttgggt tcaatatacg gagagtgccc tgtgccaaag ccacgagttg atcgtccaag aaaagttcct gtgatacaag aggagagggc aatgcctgcc cagttaagaa gaatggaaga atctcatcaa gaagcaacag agaaagaagt agaaagaatc ttgggattgt tgcagacata ttttcgagaa gatcgagaca gtctcactct ttcgcccaga ctggaatgca gtggcaccat ctcaactcac tgcaacctcc acctcctgga ttcaagcaat tctcctgcct cagcctcctg Protein function: Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus. [The UniProt Consortium]