NSFL1C (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1113 Sequence: atggcggcgg agcgacagga ggcgctgagg gagttcgtgg cggtgacggg cgccgaggag gaccgggccc gcttctttct cgagtcggcc ggctgggact tgcagatcgc gctagcgagc ttttatgagg acggagggga tgaagacatt gtgaccattt cgcaggcaac ccccagttca gtgtccagag gcacagcccc cagtgataat agagtgacat ccttcagaga cctcattcat gaccaagatg aagatgagga ggaagaggaa ggccagaggt tttatgctgg gggctcagag agaagtggac agcagattgt tggccctccc aggaagaaaa gtcccaacga gctggtggat gatctcttta aaggtgccaa agagcatgga gctgtagctg tggagcgagt gaccaagagc cctggagaga ccagtaaacc gagaccattt gcaggaggtg gctaccgcct tggggcagca ccagaggaag agtctgccta tgtggcagga gaaaagaggc agcattccag ccaagatgtt catgtagtat tgaaactctg gaagagtgga ttcagcctgg ataatggaga actcagaagc taccaagacc catccaatgc ccagtttctg gagtctatcc gcagagggga ggtgccagca gagcttcgga ggctagctca cggtggacag gtgaacttgg atatggagga ccatcgggac gaggactttg tgaagcccaa aggagccttc aaagccttca ctggcgaggg tcagaaactg ggcagcactg ccccccaggt gttgagtacc agctctccag cccaacaggc agaaaatgaa gccaaagcca gctcttccat cttaatcgac gaatcagagc ctaccacaaa catccaaatt cggcttgcag acggcgggag gctggtgcag aaatttaacc acagccacag gatcagcgac atccgactct tcatcgtgga tgcccggcca gccatggctg ccaccagctt tatcctcatg actactttcc cgaacaaaga gctggctgat gagagccaga ccctgaagga agccaacctg ctcaatgctg tcatcgtgca gcggttaaca Protein function: Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP- mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). [The UniProt Consortium]