NR1D1 (Vector pUC, Accession No. BC047875)

NR1D1 (Vector pUC, Accession No. BC047875)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CSB-CL016043HU.10 10 µg - - -

10 - 14 business days*

675.00€
 
Length: 1845 Sequence: ATGACGACCC TGGACTCCAA CAACAACACA GGTGGCGTCA TCACCTACAT TGGCTCCAGT... more
Product information "NR1D1 (Vector pUC, Accession No. BC047875)"
Length: 1845 Sequence: ATGACGACCC TGGACTCCAA CAACAACACA GGTGGCGTCA TCACCTACAT TGGCTCCAGT GGCTCCTCCC CAAGCCGCAC CAGCCCTGAA TCCCTCTATA GTGACAACTC CAATGGCAGC TTCCAGTCCC TGACCCAAGG CTGTCCCACC TACTTCCCAC CATCCCCCAC TGGCTCCCTC ACCCAAGACC CGGCTCGCTC CTTTGGGAGC ATTCCACCCA GCCTGAGTGA TGACGGCTCC CCTTCTTCCT CATCTTCCTC GTCGTCATCC TCCTCCTCCT TCTATAATGG GAGCCCCCCT GGGAGTCTAC AAGTGGCCAT GGAGGACAGC AGCCGAGTGT CCCCCAGCAA GAGCACCAGC AACATCACCA AGCTGAATGG CATGGTGTTA CTGTGTAAAG TGTGTGGGGA CGTTGCCTCG GGCTTCCACT ACGGTGTGCA CGCCTGCGAG GGCTGCAAGG GCTTTTTCCG TCGGAGCATC CAGCAGAACA TCCAGTACAA AAGGTGTCTG AAGAATGAGA ATTGCTCCAT CGTCCGCATC AATCGCAACC GCTGCCAGCA ATGTCGCTTC AAGAAGTGTC TCTCTGTGGG CATGTCTCGA GACGCTGTGC GTTTTGGGCG CATCCCCAAA CGAGAGAAGC AGCGGATGCT TGCTGAGATG CAGAGTGCCA TGAACCTGGC CAACAACCAG TTGAGCAGCC AGTGCCCGCT GGAGACTTCA CCCACCCAGC ACCCCACCCC AGGCCCCATG GGCCCCTCGC CACCCCCTGC TCCGGTCCCC TCACCCCTGG TGGGCTTCTC CCAGTTTCCA CAACAGCTGA CGCCTCCCAG ATCCCCAAGC CCTGAGCCCA CAGTGGAGGA TGTGATATCC CAGGTGGCCC GGGCCCATCG AGAGATCTTC ACCTACGCCC ATGACAAGCT GGGCAGCTCA CCTGGCAACT TCAATGCCAA CCATGCATCA GGTAGCCCTC CAGCCACCAC CCCACATCGC TGGGAAAATC AGGGCTGCCC ACCTGCCCCC AATGACAACA ACACCTTGGC TGCCCAGCGT CATAACGAGG CCCTAAATGG TCTGCGCCAG GCTCCCTCCT CCTACCCTCC CACCTGGCCT CCTGGCCCTG CACACCACAG CTGCCACCAG TCCAACAGCA ACGGGCACCG TCTATGCCCC ACCCACGTGT ATGCAGCCCC AGAAGGCAAG GCACCTGCCA ACAGTCCCCG GCAGGGCAAC TCAAAGAATG TTCTGCTGGC ATGTCCTATG AACATGTACC CGCATGGACG CAGTGGGCGA ACGGTGCAGG AGATCTGGGA GGATTTCTCC ATGAGCTTCA CGCCCGCTGT GCGGGAGGTG GTAGAGTTTG CCAAACACAT CCCGGGCTTC CGTGACCTTT CTCAGCATGA CCAAGTCACC CTGCTTAAGG CTGGCACCTT TGAGGTGCTG ATGGTGCGCT TTGCTTCGTT GTTCAACGTG AAGGACCAGA CAGTGATGTT CCTAAGCCGC ACCACCTACA GCCTGCAGGA GCTTGGTGCC ATGGGCATGG GAGACCTGCT CAGTGCCATG TTCGACTTCA GCGAGAAGCT CAACTCCCTG GCGCTTACCG AGGAGGAGCT GGGCCTCTTC ACCGCGGTGG TGCTTGTCTC TGCAGACCGC TCGGGCATGG AGAATTCCGC TTCGGTGGAG CAGCTCCAGG AGACGCTGCT GCGGGCTCTT CGGGCTCTGG TGCTGAAGAA CCGGCCCTTG GAGACTTCCC GCTTCACCAA GCTGCTGCTC AAGCTGCCGG ACCTGCGGAC CCTGAACAAC ATGCATTCCG AGAAGCTGCT GTCCTTCCGG GTGGACGCCC Protein function: Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs), represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha- cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose- induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy, controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT), imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner. Represses the transcription of CYP2B10, CYP4A10 and CYP4A14. Represses the transcription of CES2. Represses and regulates the circadian expression of TSHB in a NCOR1- dependent manner. Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity. Plays a critical role in the circadian control of neutrophilic inflammation in the lung, under resting, non- stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response. Plays a key role in the circadian regulation of microglial activation and neuroinflammation, suppresses microglial activation through the NF-kappaB pathway in the central nervous system. Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle. [The UniProt Consortium]
Keywords: EAR1, NR1D1, EAR-1, Rev-erbA-alpha, V-erbA-related protein 1, Nuclear receptor subfamily 1 group D member 1
Supplier: Cusabio
Supplier-Nr: CL016043HU

Properties

Application: Molecular biology, clone
Species reactivity: human

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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