NOTCH2NL (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pU

Length: 711 Sequence: ATGTGTGTTA CCTACCACAA TGGCACAGGA TACTGCAAAT GTCCAGAAGG CTTCTTGGGG GAATATTGTC AACATCGAGA CCCCTGTGAG AAGAACCGCT GCCAGAATGG TGGGACTTGT GTGGCCCAGG CCATGCTGGG GAAAGCCACG TGCCGATGTG CCTCAGGGTT TACAGGAGAG GACTGCCAGT ACTCGACATC TCATCCATGC TTTGTGTCTC GACCTTGCCT GAATGGCGGC ACATGCCATA TGCTCAGCCG GGATACCTAT GAGTGCACCT GTCAAGTCGG GTTTACAGGT AAGGAGTGCC AATGGACCGA TGCCTGCCTG TCTCATCCCT GTGCAAATGG AAGTACCTGT ACCACTGTGG CCAACCAGTT CTCCTGCAAA TGCCTCACAG GCTTCACAGG GCAGAAGTGT GAGACTGATG TCAATGAGTG TGACATTCCA GGACACTGCC AGCATGGTGG CACCTGCCTC AACCTGCCTG GTTCCTACCA GTGCCAGTGC CTTCAGGGCT TCACAGGCCA GTACTGTGAC AGCCTGTATG TGCCCTGTGC ACCCTCGCCT TGTGTCAATG GAGGCACCTG TCGGCAGACT GGTGACTTCA CTTTTGAGTG CAACTGCCTT CCAGAAACAG TGAGAAGAGG AACAGAGCTC TGGGAAAGAG ACAGGGAAGT CTGGAATGGA AAAGAACACG ATGAGAATTA Protein function: Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell- autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation. [The UniProt Consortium]