NMNAT3 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 648 Sequence: atgtaccagg tcatccaggg tatcatctct cctgtcaacg acacctatgg gaagaaagac ctcgcagctt ctcatcaccg agtggccatg gcccggctgg ccctgcagac atccgactgg atccgggtgg acccttggga gagtgagcag gcacagtgga tggagacagt gaaggtgctg aggcatcatc acagcaaact gctcagatct ccaccccaga tggaaggccc agaccatggc aaggcactct tctcgacccc tgcagctgtg cctgagctga agcttctctg tggggcagac gtcttgaaga ccttccagac ccccaacctc tggaaggatg cgcacatcca ggaaatagtg gagaagtttg gcttggtgtg cgtgggccga gtaggtcacg acccaaaagg ttacatcgca gaatctccca tcctacggat gcaccagcac aacattcacc tggccaagga gcctgtgcag aatgagatca gtgccacata catcaggcga gccttgggcc aagggcagag cgtaaagtac ctgattcccg atgctgtcat cacgtacatc aaggaccatg gcctctacac caagggcagt acctggaaag gcaaaagcac ccagagcact gagggcaaga Protein function: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form, nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. [The UniProt Consortium]