NLRX1 (Vector pENTR223.1, Accession No. BC013199)

Length: 2079 Sequence: atggctgctg ctgggtccca cctcctcttt gtgctccatg gcttagagca tctcaacctc gacttccggc tggcaggcac gggactttgt agtgacccgg aggaaccgca ggaaccagct gctatcatcg tcaacctgct gcgcaaatac atgctgcctc aggccagcat tctggtgacc actcggccct ctgccattgg ccgtatcccc agcaagtacg tgggccgcta tggtgagatc tgcggtttct ctgataccaa cctgcagaag ctctacttcc agctccgcct caaccagccg tactgcgggt atgccgttgg cggttcaggt gtctctgcca caccagctca gcgtgaccac ctggtgcaga tgctctcccg gaacctggag gggcaccacc agatagccgc tgcctgcttc ctgccgtcct attgctggct cgtttgtgcc accttgcact tcctgcatgc ccccacgcct gctgggcaga cccttacaag catctatacc agcttcctgc gcctcaactt cagcggggaa accctggaca gcactgaccc ctccaatttg tccctgatgg cctatgcagc ccgaaccatg ggcaagttgg cctatgaggg ggtgtcctcc cgcaagacct acttctctga agaggatgtc tgtggctgcc tggaggctgg catcaggacg gaggaggagt ttcagctgct gcacatcttc cgtcgggatg ccctgaggtt tttcctggcc ccatgtgtgg agccagggcg tgcaggcacc ttcgtgttca ccgtgcccgc catgcaggaa tacctggctg ccctctacat tgtgctgggt ttgcgcaaga cgaccctgca aaaggtgggc aaggaagtgg ctgagctcgt gggccgtgtt ggggaggacg tcagcctggt actgggcatc atggccaagc tgctgcctct gcgggctctg cctctgctct tcaacctgat caaggtggtt ccacgagtgt ttgggcgcat ggtgggtaaa agccgggagg cggtggctca ggccatggtg ctggagatgt ttcgagagga ggactactac aacgatgatg ttctggacca gatgggcgcc agtatcctgg gcgtggaggg cccccggcgc cacccagatg agccccctga ggatgaagtc ttcgagctct tccccatgtt catggggggg cttctctctg cccacaaccg agctgtgcta gctcagcttg gctgccccat caagaacctg gatgccctgg agaatgccca ggccatcaag aagaagctgg gcaagctggg ccggcaggtg ctgcccccat cagagctcct tgaccacctc ttcttccact atgagttcca gaaccagcgc ttctccgctg aggtgctcag ctccctgcgt cagctcaacc tggcaggtgt gcgcatgaca ccagtcaagt gcacagtggt ggcagctgtg ctgggcagcg gaaggcatgc cctggatgag gtgaacttgg cctcctgcca gctagatcct gctgggctgc gcacactcct gcctgtcttc ctgcgtgccc ggaagctggg cttgcaactc aacagcctgg gccctgaggc ctgcaaggac ctccgagacc tgttgctgca tgaccagtgc caaattacca cactgcggct gtccaacaac ccgctgacgg aggcaggtgt tgccgtgcta atggaggggc tggcaggaaa cacctcagtg acgcacctgt ccctgctgca cacgggcctt ggggacgaag gcctggagct gctggctgcc cagctggacc gcaaccggca gctgcaggag ctgaacgtgg cgtacaacgg tgctggtgac acagcggccc tggccctggc cagagctgcc cgggagcacc cttccctgga actgctacag ggtgtcgcca tccagatgtg ttggaagctt cccctcctgc cttatgctca cctgtggaca ccgaggatgc cctcacattg gtgctttctc ctcatcctca tgcccccttt gccacaatgg tatgatggct tggtagcccc tcgaggcaga Protein function: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352). Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). [The UniProt Consortium]