NKX2-5 (Vector pUC, Accession No. BC025711)

Length: 975 Sequence: atgttcccca gccctgctct cacgcccacg cccttctcag tcaaagacat cctaaacctg gaacagcagc agcgcagcct ggctgccgcc ggagagctct ctgcccgcct ggaggcgacc ctggcgccct cctcctgcat gctggccgcc ttcaagccag aggcctacgc tgggcccgag gcggctgcgc cgggcctccc agagctgcgc gcagagctgg gccgcgcgcc ttcaccggcc aagtgtgcgt ctgcctttcc cgccgccccc gccttctatc cacgtgccta cagcgacccc gacccagcca aggaccctag agccgaaaag aaagagctgt gcgcgctgca gaaggcggtg gagctggaga agacagaggc ggacaacgcg gagcggcccc gggcgcgacg gcggaggaag ccgcgcgtgc tcttctcgca ggcgcaggtc tatgagctgg agcggcgctt caagcagcag cggtacctgt cggcccccga acgcgaccag ctggccagcg tgctgaaact cacgtccacg caggtcaaga tctggttcca gaaccggcgc tacaagtgca agcggcagcg gcaggaccag actctggagc tggtggggct gcccccgccg ccgccgccgc ctgcccgcag gatcgcggtg ccagtgctgg tgcgcgatgg caagccatgc ctaggggact cggcgcccta cgcgcctgcc tacggcgtgg gcctcaatcc ctacggttat aacgcctacc ccgcctatcc gggttacggc ggcgcggcct gcagccctgg ctacagctgc actgccgctt accccgccgg gccttcccca gcgcagccgg ccactgccgc cgccaacaac aacttcgtga acttcggcgt cggggacttg aatgcggttc agagccccgg gattccgcag agcaactcgg gagtgtccac gctgcatggt atccgagcct Protein function: Transcription factor required for the development of the heart and the spleen (PubMed:22560297). During heart development, acts as a transcriptional activator of ANF in cooperation with GATA4. Binds to the core DNA motif of NPPA promoter (PubMed:22849347, PubMed:26926761). Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression (PubMed:22560297). [The UniProt Consortium]