NFE2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 1122 Sequence: atgtccccgt gtcctcccca gcagagcagg aacagggtga tacagctgtc cacttcagag ctaggagaga tggaactgac ttggcaggag atcatgtcca tcaccgagct gcagggtctg aatgctccaa gtgagccatc atttgagccc caagccccag ctccatacct tggacctcca ccacccacaa cttactgccc ctgctcaatc cacccagatt ctggcttccc acttcctcca ccaccttatg agctcccagc atccacatcc catgtcccag atcccccata ctcctatggc aacatggcca taccagtctc caagccactg agcctctcag gcctgctcag tgagccgctc caagacccct tagccctcct ggacattggg ctgccagcag ggccacctaa gccccaagaa gacccagaat ccgactcagg attatccctc aactatagcg atgctgaatc tcttgagctg gaggggacag aggctggtcg gcggcgcagc gaatatgtag agatgtaccc agtggagtac ccctactcac tcatgcccaa ctccttggcc cactccaact ataccttgcc agctgctgag acccccttgg ccttagagcc ctcctcaggc cctgtgcggg ctaagcccac tgcacggggg gaggcaggga gtcgggatga acgtcgggcc ttggccatga agattccttt tcctacggac aagattgtca acttgccggt agatgacttt aatgagctat tggcaaggta cccgctgaca gagagccagc tagcgctagt ccgggacatc cgacgacggg gcaaaaacaa ggtggcagcc cagaactgcc gcaagaggaa gctggaaacc attgtgcagc tggagcggga gctggagcgg ctgaccaatg aacgggagcg gcttctcagg gcccgcgggg aggcagaccg gaccctggag gtcatgcgcc aacagctgac agagctgtac cgtgacattt tccagcacct tcgggatgaa tcaggcaaca gctactctcc tgaagagtac gcgctgcaac aggctgccga tgggaccatc ttccttgtgc cccgggggac caagatggag gccacagact Protein function: Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1- like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron. [The UniProt Consortium]