NEU4 (Vector pUC, Accession No. BC012899)

Length: 693 Sequence: atgctggcac gggcaccgtc ttcctcttct tcatcgcggt gctgggccac acgcctgagg ccgtgcagat cgccacggga aggaacgccg cgcgcctctg ctgtgtggcc agccgtgacg ccggcctctc gtggggcagc gcccgggacc tcaccgagga ggccatcggt ggtgccgtgc aggactgggc cacattcgct gtgggtcccg gccacggcgt gcagctgccc tcaggccgcc tgctggtacc cgcctacacc taccgcgtgg accgccgaga gtgttttggc aagatctgcc ggaccagccc tcactccttc gccttctaca gcgatgacca cggccgcacc tggcgctgtg gaggcctcgt gcccaacctg cgctcaggcg agtgccagct ggcggcggtg gacggtgggc aggccggcag cttcctctac tgcaatgccc ggagcccact gggcagccgt gtgcaggcgc tcagcactga cgagggcacc tccttcctgc ccgcagagcg cgtggcttcc ctgcccgaga ctgcctgggg ctgccagggc agcatcgtgg gcttcccagc ccccgccccc aacaggccac gggatgacag ttggtcagtg ggccccggga gtcccctcca gcctccactc ctcggtcctg gagtccacga acccccagag gaggctgctg Protein function: Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha- (2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:15847605, PubMed:21521691, PubMed:15213228). Hydrolyzes poly- alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons. May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation (PubMed:21521691). Has sialidase activity toward mucin, fetuin and sialyllactose (PubMed:15847605). [The UniProt Consortium]