NEU2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 1143 Sequence: ATGGCGTCCC TTCCTGTCCT GCAGAAGGAG AGCGTGTTCC AGTCGGGAGC CCATGCCTAC AGAATCCCTG CCCTGCTCTA CCTGCCTGGG CAGCAGTCCC TGCTGGCCTT CGCGGAACAG CGGGCAAGCA AGAAGGATGA GCACGCAGAG CTGATTGTCC TGCGCAGAGG AGACTACGAC GCACCCACCC ACCAGGTTCA GTGGCAAGCT CAGGAGGTGG TGGCCCAGGC CCGGCTGGAT GGCCACCGGT CCATGAACCC ATGCCCCTTG TATGACGCGC AGACGGGGAC CCTCTTCCTC TTCTTCATTG CCATCCCTGG GCAAGTCACG GAGCAACAGC AGCTGCAGAC CAGGGCCAAT GTGACGCGGC TGTGCCAAGT CACCAGCACT GACCACGGGA GGACCTGGAG CTCCCCCAGA GACCTCACTG ATGCGGCCAT CGGCCCAGCC TACCGGGAGT GGTCCACCTT TGCAGTGGGC CCGGGGCATT GTTTGCAGCT TAACGACAGG GCCCGGAGCC TGGTGGTGCC CGCCTACGCC TACCGGAAAC TTCACCCCAT CCAAAGGCCG ATCCCCTCTG CCTTCTGCTT CCTCAGCCAT GACCATGGGC GCACGTGGGC GCGAGGGCAC TTTGTGGCCC AGGACACCCT GGAGTGCCAG GTGGCCGAAG TCGAGACTGG GGAGCAGAGG GTGGTGACCC TCAACGCGAG AAGCCACCTC CGAGCCAGGG TCCAGGCCCA GAGCACCAAT GACGGGCTTG ATTTCCAGGA GTCTCAGCTG GTGAAGAAGC TGGTGGAGCC GCCGCCCCAG GGCTGCCAGG GGAGCGTCAT CAGCTTCCCC AGCCCCCGCT CGGGGCCTGG CTCCCCAGCC CAGTGGCTGC TCTACACTCA CCCCACACAC TCCTGGCAGA GGGCCGACCT GGGTGCCTAC CTCAACCCGC GACCTCCAGC CCCTGAGGCC TGGTCAGAGC CGGTACTGCT GGCCAAGGGC AGCTGTGCCT ACTCAGACCT CCAGAGCATG GGCACCGGCC CTGATGGGTC CCCCTTGTTT GGGTGTCTGT ACGAAGCCAA TGATTACGAG GAGATTGTCT TTCTCATGTT CACCCTGAAG CAAGCCTTCC CAGCTGAGTA CCTGCCTCAG Protein function: Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides (PubMed:14613940, PubMed:22228546). Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha- (2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)- sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form (PubMed:14613940). Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. Cleaves milk oligosaccharide alpha- (2->3)-sialyllactose, but is inactive toward alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homopolymer of alpha- (2->8)-linked Neu5Ac residues (PubMed:14613940). [The UniProt Consortium]