NDST1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1671 Sequence: atgcctgccc tggcatgcct ccggaggctg tgtcggcacg tgtccccgca ggctgtcctt ttcctgctgc aagtcgtctg ccagttcagc gttttcatct cggcctacta cctatatggc tggaagcgag gcctggagcc ctcggcggat gcccccgagc ctgactgcgg ggacccgccg cctgtggccc ccagtcgcct gctgccactc aagcctgtgc aggcagccac cccttcccgc acagacccgt tggtgctggt ctttgtggag agcctctact cgcaactggg ccaggaggtg gtggccatcc tggagtccag ccgcttcaaa taccgcacag agattgcgcc gggcaagggt gacatgccca cgctcactga caagggccgt ggccgcttcg ccctcatcat ctatgagaac atcctcaagt atgtcaacct ggacgcctgg aaccgggagc tgctggacaa gtactgtgtg gcctacggcg tgggcatcat tggcttcttc aaggccaatg agaacagcct gctgagtgcg cagctcaagg gcttccccct gttcctgcac tcaaacctgg gcctgaagga ctgcagcatc aaccccaagt ccccgctgct ctacgtgacg cgacctagcg aggtggagaa aggtgtgctc cccggcgagg actggacggt tttccagtca aatcactcca cctatgagcc agtgctgctg gccaagacgc gctcgtctga gtccatccca cacctgggcg cagacgccgg cctgcatgct gcactgcacg ccactgtggt ccaggacctg ggcctgcacg acggcatcca gcgcgtgctg tttggcaaca acctgaactt ctggctgcac aagcttgtct tcgtggatgc cgtggccttc ctcacgggga agcgcctctc cctgccattg gaccgctaca tcctggtgga cattgatgac atcttcgtgg gcaaggaggg cacacgcatg aaggtggagg acgtgaaggc cctgtttgac acacagaacg aactacgcgc acacatccca aacttcacct tcaacctggg ctactcaggg aaattcttcc agacaggtac caatgctgag gacgctgggg atgatctgct gctgtcgtat gtgaaggagt tctggtggtt cccccacatg tggagccaca tgcagcccca ccttttccac aaccagtccg tgttggccga gcagatggcc ttgaacaaga agttcgctgt cgagcatggc attcccacag acatggggta tgcagtggcg ccccaccact cgggcgtgta ccccgtgcac gtgcagctgt acgaggcttg gaagcaggtg tggagcatcc gcgtgaccag cacggaggag tacccccacc tgaagccagc ccgctaccgc cgtggcttca tccacaatgg catcatggtt ctcccacggc agacctgcgg cctcttcaca cacaccatct tctacaacga gtaccctggc ggctccagtg agctggacaa gatcatcaac gggggcgagc tcttcctcac cgtgctcctc aatcctgtga gtgctccaca gcccatggct gctggtgaga aggggctgct gcacagcctg tctgcagctg acacaggctt cctggagcca ggaaagggtg gagaggcatg Protein function: Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (PubMed:10758005, PubMed:12634318). Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (PubMed:10758005, PubMed:12634318). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). [The UniProt Consortium]