NDFIP2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 729 Sequence: atggatcacc accagccggg gactgggcgc taccaggtgc ttcttaatga agaggataac tcagaatcat cggctataga gcagccacct acttcaaacc cagcaccgca gattgtgcag gctgcgtctt cagcaccagc acttgaaact gactcttccc ctccaccata tagtagtatt actgtggaag tacctacaac ttcagataca gaagtttacg gtgagtttta tcccgtgcca cctccctata gcgttgctac ctctcttcct acatacgatg aagctgagaa ggctaaagct gctgcaatgg cagctgcagc agcagaaaca tctcaaagaa ttcaggagga agagtgtcca ccaagagatg acttcagtga tgcagaccag ctcagagtgg ggaatgatgg cattttcatg ctggcatttt tcatggcatt tattttcaac tggcttggat tttgtttatc cttctgtatc accaatacca tagctggaag gtatggtgct atctgcggat ttggcctttc cttgatcaaa tggatcctta ttgtcaggtt ttctgattat tttactggat atttcaatgg acagtattgg ctttggtgga tatttcttgt acttggcctg ctccttttct tcagaggatt tgttaattat ctaaaagtca gaaacatgtc tgaaagtatg gcagctgctc atagaacaag gtatttcttc Protein function: Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003). May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination. [The UniProt Consortium]