NCOA3 (Vector pUC, Accession No. BC119001)

Length: 4263 Sequence: ATGAGTGGAT TAGGAGAAAA CTTGGATCCA CTGGCCAGTG ATTCACGAAA ACGCAAATTG CCATGTGATA CTCCAGGACA AGGTCTTACC TGCAGTGGTG AAAAACGGAG ACGGGAGCAG GAAAGTAAAT ATATTGAAGA ATTGGCTGAG CTGATATCTG CCAATCTTAG TGATATTGAC AATTTCAATG TCAAACCAGA TAAATGTGCG ATTTTAAAGG AAACAGTAAG ACAGATACGT CAAATAAAAG AGCAAGGAAA AACTATTTCC AATGATGATG ATGTTCAAAA AGCCGATGTA TCTTCTACAG GGCAGGGAGT TATTGATAAA GACTCCTTAG GACCGCTTTT ACTTCAGGCA TTGGATGGTT TCCTATTTGT GGTGAATCGA GACGGAAACA TTGTATTTGT ATCAGAAAAT GTCACACAAT ACCTGCAATA TAAGCAAGAG GACCTGGTTA ACACAAGTGT TTACAATATC TTACATGAAG AAGACAGAAA GGATTTTCTT AAGAATTTAC CAAAATCTAC AGTTAATGGA GTTTCCTGGA CAAATGAGAC CCAAAGACAA AAAAGCCATA CATTTAATTG CCGTATGTTG ATGAAAACAC CACATGATAT TCTGGAAGAC ATAAACGCCA GTCCTGAAAT GCGCCAGAGA TATGAAACAA TGCAGTGCTT TGCCCTGTCT CAGCCACGAG CTATGATGGA GGAAGGGGAA GATTTGCAAT CTTGTATGAT CTGTGTGGCA CGCCGCATTA CTACAGGAGA AAGAACATTT CCATCAAACC CTGAGAGCTT TATTACCAGA CATGATCTTT CAGGAAAGGT TGTCAATATA GATACAAATT CACTGAGATC CTCCATGAGG CCTGGCTTTG AAGATATAAT CCGAAGGTGT ATTCAGAGAT TTTTTAGTCT AAATGATGGG CAGTCATGGT CCCAGAAACG TCACTATCAA GAAGCTTATC TTAATGGCCA TGCAGAAACC CCAGTATATC GATTCTCGTT GGCTGATGGA ACTATAGTGA CTGCACAGAC AAAAAGCAAA CTCTTCCGAA ATCCTGTAAC AAATGATCGA CATGGCTTTG TCTCAACCCA CTTCCTTCAG AGAGAACAGA ATGGATATAG ACCAAACCCA AATCCTGTTG GACAAGGGAT TAGACCACCT ATGGCTGGAT GCAACAGTTC GGTAGGCGGC ATGAGTATGT CGCCAAACCA AGGCTTACAG ATGCCGAGCA GCAGGGCCTA TGGCTTGGCA GACCCTAGCA CCACAGGGCA GATGAGTGGA GCTAGGTATG GGGGTTCCAG TAACATAGCT TCATTGACCC CTGGGCCAGG CATGCAATCA CCATCTTCCT ACCAGAACAA CAACTATGGG CTCAACATGA GTAGCCCCCC ACATGGGAGT CCTGGTCTTG CCCCAAACCA GCAGAATATC ATGATTTCTC CTCGTAATCG TGGGAGTCCA AAGATAGCCT CACATCAGTT TTCTCCTGTT GCAGGTGTGC ACTCTCCCAT GGCATCTTCT GGCAATACTG GGAACCACAG CTTTTCCAGC AGCTCTCTCA GTGCCCTGCA AGCCATCAGT GAAGGTGTGG GGACTTCCCT TTTATCTACT CTGTCATCAC CAGGCCCCAA ATTGGATAAC TCTCCCAATA TGAATATTAC CCAACCAAGT AAAGTAAGCA ATCAGGATTC CAAGAGTCCT CTGGGCTTTT ATTGCGACCA AAATCCAGTG GAGAGTTCAA TGTGTCAGTC AAATAGCAGA GATCACCTCA GTGACAAAGA AAGTAAGGAG AGCAGTGTTG AGGGGGCAGA GAATCAAAGG GGTCCTTTGG AAAGCAAAGG TCATAAAAAA TTACTGCAGT TACTTACCTG TTCTTCTGAT GACCGGGGTC ATTCCTCCTT GACCAACTCC CCCCTAGATT CAAGTTGTAA AGAATCTTCT GTTAGTGTCA CCAGCCCCTC TGGAGTCTCC TCCTCTACAT CTGGAGGAGT ATCCTCTACA TCCAATATGC ATGGGTCACT GTTACAAGAG AAGCACCGGA TTTTGCACAA GTTGCTGCAG AATGGGAATT CACCAGCTGA GGTAGCCAAG ATTACTGCAG AAGCCACTGG GAAAGACACC AGCAGTATAA CTTCTTGTGG GGACGGAAAT GTTGTCAAGC AGGAGCAGCT AAGTCCTAAG AAGAAGGAGA ATAATGCACT TCTTAGATAC CTGCTGGACA GGGATGATCC TAGTGATGCA CTCTCTAAAG AACTACAGCC CCAAGTGGAA GGAGTGGATA ATAAAATGAG TCAGTGCACC AGCTCCACCA TTCCTAGCTC AAGTCAAGAG AAAGACCCTA AAATTAAGAC AGAGACAAGT GAAGAGGGAT CTGGAGACTT GGATAATCTA GATGCTATTC TTGGTGATCT GACTAGTTCT GACTTTTACA ATAATTCCAT ATCCTCAAAT GGTAGTCATC TGGGGACTAA GCAACAGGTG TTTCAAGGAA CTAATTCTCT GGGTTTGAAA AGTTCACAGT CTGTGCAGTC TATTCGTCCT CCATATAACC GAGCAGTGTC TCTGGATAGC CCTGTTTCTG TTGGCTCAAG TCCTCCAGTA AAAAATATCA GTGCTTTCCC CATGTTACCA AAGCAACCCA TGTTGGGTGG GAATCCAAGA ATGATGGATA GTCAGGAAAA TTATGGCTCA AGTATGGGTG GGCCAAACCG AAATGTGACT GTGACTCAGA CTCCTTCCTC AGGAGACTGG GGCTTACCAA ACTCAAAGGC CGGCAGAATG GAACCTATGA ATTCAAACTC CATGGGAAGA CCAGGAGGAG ATTATAATAC TTCTTTACCC AGACCTGCAC TGGGTGGCTC TATTCCCACA TTGCCTCTTC GGTCTAATAG CATACCAGGT GCGAGACCAG TATTGCAACA GCAGCAGCAG ATGCTTCAAA TGAGGCCTGG TGAAATCCCC ATGGGAATGG GGGCTAATCC CTATGGCCAA GCAGCAGCAT CTAACCAACT GGGTTCCTGG CCCGATGGCA TGTTGTCCAT GGAACAAGTT TCTCATGGCA CTCAAAATAG GCCTCTTCTT AGGAATTCCC TGGATGATCT TGTTGGGCCA CCTTCCAACC TGGAAGGCCA GAGTGACGAA AGAGCATTAT TGGACCAGCT GCACACTCTT CTCAGCAACA CAGATGCCAC AGGCCTGGAA GAAATTGACA GAGCTTTGGG CATTCCTGAA CTTGTCAATC AGGGACAGGC ATTAGAGCCC AAACAGGATG CTTTCCAAGG CCAAGAAGCA GCAGTAATGA TGGATCAGAA GGCAGGATTA TATGGACAGA CATACCCAGC ACAGGGGCCT CCAATGCAAG GAGGCTTTCA TCTTCAGGGA CAATCACCAT CTTTTAACTC TATGATGAAT CAGATGAACC AGCAAGGCAA TTTTCCTCTC CAAGGAATGC ACCCACGAGC CAACATCATG AGACCCCGGA CAAACACCCC CAAGCAACTT AGAATGCAGC TTCAGCAGAG GCTGCAGGGC CAGCAGTTTT TGAATCAGAG CCGACAGGCA CTTGAATTGA AAATGGAAAA CCCTACTGCT GGTGGTGCTG CGGTGATGAG GCCTATGATG CAGCCCCAGC AGGGTTTTCT TAATGCTCAA ATGGTCGCCC AACGCAGCAG AGAGCTGCTA AGTCATCACT TCCGACAACA GAGGGTGGCT ATGATGATGC AGCAGCAGCA GCAGCAGCAA CAGCAGCAGC AGCAGCAGCA GCAGCAGCAA CAGCAACAGC AACAGCAACA GCAGCAACAG CAGCAAACCC AGGCCTTCAG CCCACCTCCT AATGTGACTG CTTCCCCCAG CATGGATGGG CTTTTGGCAG GACCCACAAT GCCACAAGCT CCTCCGCAAC AGTTTCCATA TCAACCAAAT TATGGAATGG GACAACAACC AGATCCAGCC TTTGGTCGAG TGTCTAGTCC TCCCAATGCA ATGATGTCGT CAAGAATGGG TCCCTCCCAG AATCCCATGA TGCAACACCC GCAGGCTGCA TCCATCTATC AGTCCTCAGA AATGAAGGGC TGGCCATCAG GAAATTTGGC CAGGAACAGC TCCTTTTCCC AGCAGCAGTT TGCCCACCAG GGGAATCCTG CAGTGTATAG TATGGTGCAC ATGAATGGCA GCAGTGGTCA CATGGGACAG ATGAACATGA ACCCCATGCC CATGTCTGGC ATGCCTATGG GTCCTGATCA GAAATACTGC Protein function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. [The UniProt Consortium]