MYLIP (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1338 Sequence: atgctgtgtt atgtgacgag gccggacgcg gtgctgatgg aggtggaggt ggaggcgaaa gccaacggcg aggactgcct caaccaggtg tgcaggcgac tgggaatcat agaagttgac tattttggac tgcagtttac gggtagcaaa ggtgaaagtt tatggctaaa cctgagaaac cggatctccc agcagatgga tgggctagcc ccttacaggc ttaaacttag agtcaagttc ttcgtggagc ctcatctcat cttacaggag cagactaggc atatcttttt cttgcacatc aaggaggccc tcttggcagg ccacctcttg tgttccccag agcaggcagt ggaactcagt gccctcctgg cccagaccaa gtttggagac tacaaccaga acactgccaa gtataactat gaggagctct gtgccaagga gctctcctct gccaccttga acagcattgt tgcaaaacat aaggagttgg aggggaccag ccaggcttca gctgaatacc aagttttgca gattgtgtcg gcaatggaaa actatggcat agaatggcat tctgtgcggg atagcgaagg gcagaaactg ctcattgggg ttggacctga aggaatctca atttgtaaag atgactttag cccaattaat aggatagctt atcctgtggt gcagatggcc acccagtcag gaaagaatgt atatttgacg gtcaccaagg aatctgggaa cagcatcgtg ctcttgttta aaatgatcag caccagggcg gccagcgggc tctaccgagc gataacagag acgcacgcat tctacaggtg tgacacagtg accagcgccg tgatgatgca gtatagccgt gacttgaagg gccacttggc atctctgttt ctgaatgaaa acattaacct tggcaagaaa tatgtctttg atattaaaag aacatcaaag gaggtgtatg accatgccag gagggctctg tacaatgctg gcgttgtgga cctcgtttca agaaacaacc agagcccttc acactcgcct ctgaagtcct cagaaagcag catgaactgc agcagctgcg agggcctcag ctgccagcag acccgggtgc tgcaggagaa gctacgcaag ctgaaggaag ccatgctgtg catggtgtgc tgcgaggagg agatcaactc caccttctgt ccctgtggcc acactgtgtg ctgtgagagc tgcgccgccc agctacagtc atgtcccgtc tgcaggtcgc gtgtggagca tgtccagcac gtctatctgc caacgcacac cagtcttctc aatctgactg Protein function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. [The UniProt Consortium]