MTMR6 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1866 Sequence: atggagcata tccggacgac caaggtcgaa caagtaaaat tacttgaccg attcagtacc agcaacaagt cattaacagg aacactgtat cttacggcta cacatctatt atttatcgac tctcatcaaa aagaaacctg gatattacac caccatattg cctcagtaga gaaacttgct ttgactactt ctggatgccc ccttgtgata cagtgcaaga acttcagaac tgtgcatttc attgttccca gagaaagaga ttgccatgat atttacaact ctttgctaca actgtcaaaa caagcaaaat atgaagatct ctatgcattt tcttataatc ccaaacaaaa tgattcagaa cgactacaag gctggcagct cattgatctc gctgaggaat ataagaggat gggagtgcca aactcacact ggcagttgtc tgatgccaac cgggactaca agatttgtga aacttacccc agagaacttt atgttccccg gatagcaagc aaaccaataa ttgttggtag ttccaagttc cggagcaagg gaagattccc agttctttcc tactatcatc aagataagga ggctgccatt tgtcgatgta gtcagccact ctctggattc agtgccaggt gcctggagga tgaacatttg cttcaagcca ttagtaaagc caatccagtc aatcgctata tgtacgtcat ggataccagg ccaaaactga atgcaatggc caacagagca gctggaaaag gttatgaaaa tgaagacaac tattccaata ttagatttca gtttgttgga attgaaaata ttcatgtcat gaggtccagc cttcagaaat tattggaagt caatggcact aaagggcttt ctgtcaatga tttctactcc ggtttggaga gctcgggatg gcttcgccat atcaaagctg ttatggatgc tgcagtcttc ttggccaaag caataacagt tgaaaatgca agtgtgttgg tgcattgttc cgatggttgg gataggactt cccaggtttg ttccctgggt tctcttttat tggattccta ctacaggaca atcaaaggat tcatggtttt aatagaaaag gattggatct cttttggaca taaattttca gagaggtgtg gccagttgga tggtgaccca aaggaagtct caccagtgtt tactcagttc ttggaatgtg tgtggcattt gaccgaacag tttccacaag cctttgaatt cagtgaagca tttcttcttc agatccatga gcatattcat tcatgccagt ttggaaactt ccttggaaat tgtcagaagg aaagagaaga gctcaagttg aaggagaaga cttattccct gtggccattt cttttggaag accaaaagaa gtacttaaat cctctctaca gttccgaatc tcacagattt acagttttgg agccaaatac agtatctttc aattttaagt tttggaggaa catgtaccat cagtttgatc gaacactgca tcctaggcag tctgtattta atataattat gaatatgaat gagcaaaata aacaattaga gaaagatatt aaagacctag aatctaaaat taaacaacgc aaaaataagc aaacagatgg catcctcacc aaggaattgt tacattcagt tcatcctgaa tcacctaacc tcaaaacttc cctgtgtttt aaagagcaga ctctgctacc cgtaaatgat gctcttcgaa ctatagaggg cagcagcccg gcagataatc gttatagtga atatgcagaa gagttttcta aatcagaacc tgctgtggtc agcttagagt atggtgtggc aagaatgact Protein function: Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:19038970, PubMed:22647598). Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate (PubMed:19038970, PubMed:22647598) (Probable). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (PubMed:19038970). Negatively regulates ER-Golgi protein transport. Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate (PubMed:15831468). Negatively regulates proliferation of reactivated CD4(+) T-cells (PubMed:16847315). In complex with MTMR9, negatively regulates DNA damage-induced apoptosis (PubMed:19038970, PubMed:22647598). The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). [The UniProt Consortium]