MPEG1 (Vector pUC, Accession No. BC112230)

Length: 2151 Sequence: ATGAACAACT TCAGGGCCAC CATCCTCTTC TGGGCAGCGG CAGCATGGGC TAAATCAGGC AAGCCTTCGG GAGAGATGGA CGAAGTTGGA GTTCAAAAAT GCAAGAATGC CTTGAAACTA CCTGTCCTGG AAGTCCTACC TGGAGGGGGC TGGGACAATC TGCGGAATGT GGACATGGGA CGAGTTATGG AATTGACTTA CTCCAACTGC AGGACAACAG AGGATGGACA GTATATCATC CCTGATGAAA TCTTCACCAT TCCCCAGAAA CAGAGCAACC TGGAGATGAA CTCAGAAATC CTGGAATCCT GGGCAAATTA CCAGAGTAGC ACCTCCTACT CCATCAACAC AGAACTCTCT CTTTTTTCCA AAGTCAATGG CAAGTTTTCC ACTGAGTTCC AGAGGATGAA GACCCTCCAA GTGAAGGACC AAGCTATAAC TACCCGAGTT CAGGTAAGAA ACCTCGTCTA CACAGTCAAA ATCAACCCAA CTTTAGAGCT AAGCTCAGGT TTTAGGAAGG AACTCCTTGA CATCTCTGAC CGTCTAGAGA ACAACCAGAC GAGGATGGCC ACCTACCTGG CAGAACTCCT GGTGCTCAAC TATGGCACCC ACGTCACCAC CAGTGTCGAC GCTGGGGCTG CTCTTATTCA GGAGGACCAC CTCAGGGCCT CCTTCCTCCA AGACAGCCAG AGCAGTCGTA GTGCCGTGAC CGCCTCTGCT GGACTTGCCT TTCAAAACAC CGTGAACTTC AAATTTGAGG AAAACTATAC CTCGCAGAAT GTCCTCACCA AGAGCTACCT CTCAAACCGA ACCAACTCCA GGGTGCAGAG CATTGGAGGG GTTCCTTTTT ACCCAGGCAT CACCCTCCAG GCCTGGCAGC AGGGTATCAC CAACCACCTG GTGGCCATCG ACCGCTCTGG CCTGCCGCTG CATTTCTTCA TCAACCCCAA CATGCTACCT GACTTGCCAG GCCCCCTGGT GAAGAAGGTG TCAAAGACAG TGGAAACTGC TGTGAAGCGC TATTATACAT TCAACACCTA CCCTGGCTGC ACAGATCTCA ATTCTCCCAA CTTCAATTTT CAGGCCAACA CGGATGATGG CTCCTGCGAG GGGAAAATGA CCAACTTCTC TTTCGGTGGG GTTTATCAGG AATGCACTCA GCTCTCAGGG AATAGGGATG TCCTCCTCTG CCAAAAGTTG GAGCAGAAGA ATCCACTCAC TGGTGATTTC TCCTGCCCCT CTGGCTACTC CCCGGTGCAC CTGTTATCCC AGATCCACGA GGAGGGTTAC AACCACCTGG AGTGTCATCG AAAGTGCACT CTCCTCGTCT TCTGCAAGAC CGTGTGTGAA GATGTGTTCC AGGTGGCAAA AGCTGAATTT AGGGCTTTTT GGTGTGTGGC CAGCAGCCAA GTACCTGAAA ACTCAGGACT GCTTTTTGGG GGCCTCTTCA GCAGCAAGAG CATAAACCCC ATGACAAATG CACAGTCATG CCCAGCCGGC TACTTTCCAC TGAGACTCTT TGAAAACCTC AAGGTATGTG TTTCTCAGGA CTATGAGTTG GGAAGCAGGT TTGCGGTCCC CTTTGGCGGG TTCTTTAGCT GCACAGTTGG GAACCCCCTG GTAGATCCTG CTATATCCAG AGATTTAGGG GCACTGTCTC TGAAAAAGTG CCCCGGGGGC TTCAGCCAGC ACCCAGCCCT CATCAGCGAT GGATGCCAAG TGTCCTATTG CGTCAAATCC GGGCTCTTCA CAGGAGGGTC CCTGCCCCCT GCCAGGCTCC CACCTTTCAC CCGGCCACCC CTCATGAGTC AGGCTGCCAC CAATACTGTC ATAGTGACCA ATTCTGAGAA TGCGAGATCC TGGATTAAAG ACTCCCAGAC CCACCAGTGG AGGCTGGGAG AACCGATAGA GCTGCGGAGG GCCATGAATG TCATCCATGG GGATGGTGGT GGTCTGTCAG GAGGGGCTGC AGCTGGGGTC ACAGTGGGGG TCACCACCAT TCTGGCTGTT GTTATCACCT TGGCCATCTA CGGCACCCGG AAGTTCAAGA AGAAAGCATA TCAGGCAATT GAGGAAAGGC AGAGTTTGGT TCCAGGCACT GCAGCAACTG GAGACACCAC TTACCAAGAG CAGGGGCAGA GTCCAGCTTA Protein function: Plays a key role in the innate immune response following bacterial infection by inserting into the bacterial surface to form pores. By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence. Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria (PubMed:23753625, PubMed:26402460, PubMed:30609079). Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol. Required for the antibacterial activity of reactive oxygen species and nitric oxide. [The UniProt Consortium]