MORC2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 2913 Sequence: atgctttgct ttttggatga tggagcagga atggatccaa gtgatgctgc cagtgtgatc cagtttggga agtcggccaa gcgaacacct gagtctactc agattgggca gtacgggaat gggttaaaat cgggctcaat gcgcattggg aaggatttta tcctgttcac caagaaggaa gacaccatga cctgcctctt cctgtctcgc acgtttcatg aggaagaagg cattgatgaa gtgatagtcc cactgcccac ctggaatgct cggacccggg aacctgtcac agacaatgta gagaaatttg ccattgagac agaactcatc tataagtact ctccattccg cactgaggag gaagtgatga cccagtttat gaagattcct ggggacagcg gaacattggt gatcatcttc aatctcaaac tcatggataa tggagagcca gaactagaca taatctcaaa tccaagagat atccagatgg cagagacgtc cccagagggc acgaagccag agcggcgctc gttccgtgcc tatgccgctg tgctctatat tgatccccgg atgaggatct tcatccatgg gcacaaggtg cagaccaaga ggctctcctg ctgcctgtac aagcccagga tgtacaagta cacgtcaagc cgtttcaaga cccgtgcgga gcaggaggtg aagaaagcag agcacgtagc aaggattgct gaagagaagg cgcgggaggc agagagcaaa gctcggacat tagaagtacg cctaggtgga gacctcacgc gggactccag ggtgatgttg cgacaggtcc agaacagagc catcactctg cgcagagaag ccgatgtcaa gaagaggatc aaggaggcca agcagcgagc acttaaagaa cctaaggaac tgaattttgt ttttggtgtc aacattgaac accgggatct ggatggcatg ttcatctaca actgtagccg actgatcaaa atgtatgaga aagtgggccc acagctggaa gggggcatgg catgtggcgg ggttgttggg gttgttgatg tgccctacct ggtcctggag cctacacaca acaaacagga ctttgctgat gccaaggagt accggcacct gctccgagca atgggggagc acctggcgca gtattggaag gatattgcca tcgcccagag gggaatcatc aagttctggg atgagtttgg ctacctctct gccaactgga accagccccc atccagtgag ctgcgttaca aacgccggag agctatggaa atccccacca ccatccagtg cgatttgtgt ctgaaatgga gaaccctccc cttccagctg agttctgtgg aaaaagatta ccctgacacc tgggtttgct ccatgaaccc tgatcctgaa caggaccggt gtgaggcttc tgaacaaaag cagaaggttc ccctgggaac attcagaaag gacatgaaga cgcaggaaga gaagcagaaa caactgacag agaaaattcg ccagcagcag gagaagctgg aggcccttca gaaaaccaca cccatccgct cccaagcaga cctgaagaaa ttgcccttgg aagtgaccac cagaccttcc actgaggaac ctgtgcgtag acctcagcgt cctcggtcgc cccctttacc tgctgtgatc aggaacgccc ccagcagacc cccttctttg ccaactccta gaccagccag ccagccccga aaggctcctg tcatcagcag taccccaaag ctccctgctt tggcagcccg ggaggaggcc agcacatcta ggctgctcca gccacctgag gcaccccgaa agcctgccaa cactctcgtc aagactgcat cccgacctgc ccctctggtg cagcaactgt caccatcttt actgcccaac tccaagagcc ctcgggaggt tccttctccc aaagtcatca agactccagt ggtgaagaag acagagtcac ccatcaaact ctccccggct acccctagtc ggaagcggag tgtcgcagtt tctgatgagg aagaagttga ggaggaagct gagaggagga aggagaggtg caagcggggc agatttgttg tgaaggagga aaagaaggac tcgaatgagc tctcagacag tgctggggaa gaggactcgg ctgacctcaa gagagctcag aaagataaag ggctgcacgt ggaggtgcgt gtgaacaggg agtggtacac gggccgtgtc acagccgtgg aggtgggcaa gcatgtggtg cggtggaagg tgaagtttga ctacgtgccc acagacacga caccaagaga ccgctgggtg gagaaaggca gtgaggatgt gcggctgatg aaaccccctt ctccggaaca tcagagcctt gatacacaac aggagggcgg ggaggaggag gtgggccctg tggcccagca ggccatagct gtcgcagagc cctccacttc cgaatgcctc cgcattgagc ctgacaccac tgccctgagc accaatcacg agaccatcga cctgcttgtc cagatcctcc ggaattgttt acggtacttc ctgcctccaa gtttccccat ctccaagaag cagctgagtg ctatgaattc agatgagcta atatcttttc ctctgaagga gtacttcaag caatatgaag tagggctcca aaacctgtgc aattcctacc agagccgtgc tgactcccgg gccaaggcct ccgaggaaag cctgcgcacc tccgagagga agctccgcga gacggaggag aagctgcaga agctgaggac caacatcgtg gcactcctgc aaaaggtgca ggaggacata gacatcaaca cagatgatga gctggacgcc tacattgagg acctcatcac caagggggac Protein function: Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20225202, PubMed:20110259). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). [The UniProt Consortium]