MMAA (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 1257 Sequence: ATGCCCATGC TGCTACCACA TCCTCACCAG CATTTCCTAA AAGGCCTTTT AAGAGCACCT TTCCGATGTT ACCACTTCAT CTTTCACTCA AGTACTCATC TCGGATCAGG AATCCCATGT GCTCAGCCGT TTAATTCTCT TGGACTCCAT TGTACAAAGT GGATGCTGCT GTCAGATGGC TTAAAGAGAA AATTATGTGT ACAAACAACC TTAAAGGACC ACACAGAAGG ACTTTCTGAT AAAGAGCAAA GATTTGTGGA TAAACTTTAT ACTGGTTTAA TCCAAGGGCA AAGGGCCTGT TTAGCAGAGG CCATAACTCT TGTAGAATCA ACTCACAGCA GGAAAAAGGA GTTAGCCCAG GTGCTTCTTC AGAAAGTATT ACTTTACCAC AGAGAACAAG AACAATCAAA TAAAGGAAAA CCACTAGCAT TTCGAGTAGG ATTGTCTGGG CCCCCTGGTG CTGGAAAATC AACATTTATA GAATATTTTG GAAAAATGCT TACTGAGAGA GGGCACAAAT TATCTGTGCT AGCTGTGGAC CCTTCTTCTT GTACTAGTGG TGGATCACTC TTAGGTGATA AAACCCGAAT GACTGAGTTA TCAAGAGATA TGAATGCATA CATCAGGCCA TCTCCTACTA GAGGAACTTT AGGAGGCGTG ACAAGGACCA CAAATGAAGC TATTCTGTTG TGTGAAGGAG CGGGATATGA CATAATTCTT ATTGAAACCG TTGGTGTGGG TCAGTCGGAG TTTGCTGTTG CTGACATGGT TGACATGTTT GTTTTACTAC TGCCACCAGC AGGAGGAGAT GAGCTGCAGG GTATCAAAAG GGGTATAATC GAGATGGCAG ATCTGGTAGC TGTAACTAAA TCTGATGGAG ACTTGATTGT GCCAGCTCGA AGGATACAAG CGGAATATGT GAGTGCACTG AAATTACTCC GCAAACGTTC ACAAGTCTGG AAACCAAAGG TAATTCGTAT TTCTGCCCGA AGTGGAGAGG GGATCTCTGA AATGTGGGAT AAAATGAAAG ATTTCCAGGA CCTAATGCTT GCCAGTGGGG AGCTGACTGC CAAACGACGG AAGCAACAGA AAGTTTGGAT GTGGAATCTC ATTCAGGAAA GTGTGTTAGA GCATTTCAGG ACCCACCCCA CAGTCCGGGA ACAGATTCCA CTTCTGGAAC AAAAGGTTCT CATTGGGGCC CTGTCCCCAG GACTAGCAGC AGACTTCTTG TTAAAAGCTT TTAAAAGCAG Protein function: GTPase, binds and hydrolyzes GTP (PubMed:28497574, PubMed:20876572, PubMed:21138732, PubMed:28943303). Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis (PubMed:28497574, PubMed:20876572). Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) (PubMed:28497574, PubMed:20876572). Plays a dual role as both a protectase and a reactivase for MMUT (PubMed:21138732, PubMed:28943303). Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl) (PubMed:21138732, PubMed:28943303). Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP (PubMed:21138732, PubMed:28943303). [The UniProt Consortium]