MLL5 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 1830 Sequence: atgagcatag tgatcccatt gggggttgat acagcagaga cgtcatactt ggaaatggct gcaggttcag aaccagaatc cgtagaagct agccctgtgg tagttgagaa atccaacagt tatccccacc agttatatac cagcagctca catcattcac acagttacat tggtttgccc tatgcggacc ataattatgg tgctcgtcct cctccgacac ctccggcttc ccctcctcca tcagtcctta ttagcaaaaa tgaagtaggc atatttacca ctcctaattt tgatgaaact tccagtgcta ctacaatcag cacatctgag gatggaagtt atggtactga tgtaaccagg tgcatatgtg gttttacaca tgatgatgga tacatgatct gttgtgacaa atgcagcgtt tggcaacata ttgactgcat ggggattgat aggcagcata ttcctgatac atatctatgt gaacgttgtc agcctaggaa tttggataaa gagagggcag tgctactaca acgccggaaa agggaaaata tgtcagatgg tgataccagt gcaactgaga gtggtgatga ggttcctgtg gaattatata ctgcatttca gcatactcca acatcaatta ctttaactgc ttcaagagtt tccaaagtta atgataaaag aaggaaaaaa agcggggaga aagaacaaca catttcaaaa tgtaaaaagg catttcgtga aggatctagg aagtcatcaa gagttaaggg ttcagctcca gagattgatc cttcatctga tggttcaaat tttggatggg agacaaagat caaagcatgg atggatcgat atgaagaagc aaataacaac cagtacagtg agggtgttca gagggaggca caaagaatag ctctgagatt aggcaatgga aatgacaaaa aagagatgaa taaatccgat ttgaatacca acaatttgct cttcaaacct cctgtagaga gccatataca aaagaataag aaaattctta aatctgcaaa agatttgcct cctgatgcac ttatcattga atacagaggg aagtttatgc tgagagaaca gtttgaagca aatgggtatt tctttaaaag accataccct tttgtgttat tctactctaa atttcatggg ctagaaatgt gtgttgatgc aaggactttt gggaatgagg ctcgattcat caggcggtct tgtacaccca atgcagaggt gaggcatgaa attcaagatg gaaccataca tctttatatt tattctatac acagtattcc aaagggaact gaaattacta ttgcctttga ttttgactat ggaaattgta agtacaaggt ggactgtgca tgcctcaaag aaaacccaga gtgccctgtt ctaaaacgta gttctgaatc catggaaaat atcaatagtg gttatgagac cagacggaaa aaaggaaaaa aagacaaaga tatttcaaaa gaaaaagata cacaaaatca gaatattact ttggattgtg aaggaacgac caacaaaatg aagagcccag aaactaaaca aagaaagctt tctccactga gactatcagt atcaaataat caggaaccag attttattga tgatatagaa gaaaaaactc ctattagtaa tgaagtagaa atggaatcag aggagcagat tgcagaaagg aaaaggaaga tggtaagttg ggaagccagt agtttgggct tagtgacagc tgctctgcat atggtaattg ttgctgcctt tacatgggct tttacattat tctttgaagt Protein function: Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:24130829, PubMed:23798402). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:24130829, PubMed:23798402). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. [The UniProt Consortium]