MICAL1 (Vector pUC, Accession No. BC009972)

Length: 2946 Sequence: atggcttcac ctacctccac caacccagcg catgcccact ttgagagctt cctgcaggcc cagctgtgcc aggacgtgct gagcagcttc caggagctgt gtggggccct ggggctggaa cccggtgggg ggctgcccca gtaccacaag atcaaggacc agctcaacta ctggagcgcc aagtcactgt ggaccaagct ggacaagcga gcaggccagc ctgtctacca gcagggccgg gcctgcacca gcaccaagtg cctggtggtg ggtgctggac cttgcgggct gcgggtcgct gtggagctgg cgctgctggg ggcccgagtg gtgctggtgg aaaagcgcac caagttctct cgccacaacg tgctccacct ctggcccttc accatccacg acctgcgggc actcggtgct aagaagttct acgggcgctt ctgcaccggc accctggacc acatcagcat caggcagctc cagctgcttc tgctgaaggt agcattgctg ctgggggtgg aaattcactg gggtgtcact ttcactggcc tccagccccc tcctaggaag gggagtggct ggcgtgccca gctccaaccc aacccccctg cccagctggc caactatgaa tttgacgtcc ttatctcggc tgcaggaggt aaattcgtcc ctgaaggctt caaagttcga gaaatgcgag gcaaactggc cattggcatc acagccaact ttgtgaatgg acgcaccgtg gaggagacac aggtgccgga gatcagtggt gtagccagga tctacaacca gagcttcttc cagagccttc tcaaagccac aggcattgat ctggagaaca ttgtgtacta caaggacgac acccactact ttgtgatgac agccaagaag cagtgcctgc tgcggctggg ggtgctgcgc cagcccttct ggcccctggg cactggagtg gcacggggct tcctggcagc ctttgatgca gcctggatgg tgaagcggtg ggcagagggc gctgagtccc tagaggtgtt ggctgagcgt gagagcctgt accagcttct gtcacagaca tccccagaaa acatgcatcg caatgtggcc cagtatgggc tggacccagc cacccgctac cccaacctga acctccgggc agtgaccccc aatcaggtac gagacctgta tgatgtgcta gccaaggagc ctgtgcagag gaacaacgac aagacagata cagggatgcc agccaccggg tcggcaggca cccaggagga gctgctacgc tggtgccagg agcagacagc tgggtacccg ggagtccacg tctccgattt gtcttcctcc tgggctgatg ggctagctct gtgtgccctg gtgtaccggc tgcagcctgg cctgctggaa ccctcagagc tgcaggggct gggagctctg gaagcaactg cttgggcact aaaggtggca gagaatgagc tgggcatcac accggtggtg tctgcacagg ccgtggtagc agggagtgac ccactgggcc tcattgccta cctcagccac ttccacagtg ccttcaagag catggcccac agcccaggcc ctgtcagcca gacctcccca gggacctcca gtgctgtatt attccttagt aaacttcaga ggaccctgca gcgatcccgg gccaaggaaa atgcagagga tgctggtggc aagaagctgc gcttggagat ggaggccgag accccaagta ctgaggtgcc acctgaccca gagcctggtg tacccctgac acccccatcc caacaccagg aggccggtgc tggggacctg tgtgcacttt gtggggaaca cctctatgtc ctggaacgcc tctgtgtcaa cggccatttc ttccaccgga gctgcttccg ctgccatacc tgtgaggcca cactgtggcc aggtggctat gagcagcacc caggagatgg acatttctac tgcctccagc acctgcccca gacagaccac aaaaaggaag gcagcgatag aggccctgag agtccggagc tccccacacc aagtgagaat agcatgccac caggcctctc aactcccaca gcctcgcagg agggggccgg tcctgttcca gatcccagcc agcccacccg tcggcagatc cgcctctcca gcccggagcg ccagcggttg tcctccctta accttacccc tgacccggaa atggagcctc cacccaagcc tccccgcagc tgctccgcct tggcccgcca cgccctggag agcagctttg tgggctgggg cctgccagtc cagagccctc aagctcttgt ggccatggag aaggaggaaa aagagagtcc cttctccagt gaagaggaag aagaagatgt gcctttggac tcagatgtgg aacaggccct gcagaccttt gccaagacct caggcaccat gaataactac ccaacatggc gtcggactct gctgcgccgt gcgaaggagg aggagatgaa gaggttctgc aaggcccaga ccatccaacg gcgactaaat gagattgagg ctgccttgag ggagctagag gccgagggcg tgaagctgga gctggccttg aggcgccaga gcagttcccc agaacagcaa aagaaactat gggtaggaca gctgctacag ctcgttgaca agaaaaacag cctggtggct gaggaggccg agctcatgat cacggtgcag gaattgaatc tggaggagaa acagtggcag ctggaccagg agctacgagg ctacatgaac cgggaagaaa acctaaagac agctgctgat cggcaggctg aggaccaggt cctgaggaag ctggtggatt tggtcaacca gagagatgcc ctcatccgct tccaggagga gcgcaggctc agcgagctgg ccttggggac aggggcccag Protein function: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (PubMed:21864500, PubMed:26845023). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L, acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking. [The UniProt Consortium]