MEOX2 (Vector pUC, Accession No. BC017021)

Length: 912 Sequence: atggaacacc cgctctttgg ctgcctgcgc agccctcacg ccacggcgca aggcttgcac ccgttctccc aatcctctct cgccctccat ggaagatctg accatatgtc ttaccccgag ctctctactt cttcctcatc ttgcataatc gcgggatacc ccaacgaaga gggcatgttt gccagccagc atcacagggg gcaccaccac caccaccacc accaccatca ccaccatcag cagcagcagc accaggctct gcaaaccaac tggcacctcc cgcagatgtc ttccccaccg agtgcggctc ggcacagcct ctgcctccag cccgactctg gagggccccc agagttgggg agcagcccgc ccgtcctgtg ctccaactct tccagcttgg gctccagcac cccgactggg gccgcgtgcg cgccggggga ctacggccgc caggcactgt cacctgcgga ggcggagaag cgaagcggcg gcaagaggaa aagcgacagc tcagactccc aggaaggaaa ttacaagtca gaagtcaaca gcaaacccag gaaagaaagg acagcattta ccaaagagca aatcagagaa cttgaagcag aatttgccca tcataattat ctcaccagac tgaggcgata cgagatagca gtgaatctgg atctcactga aagacaggtg aaagtctggt tccaaaacag gcggatgaag tggaagaggg taaagggtgg acagcaagga gctgcggctc gggaaaagga actggtgaat gtgaaaaagg gaacacttct cccatcagag ctgtcgggaa ttggtgcagc caccctccag caaacagggg actctatagc aaatgaagac agtcacgaca gtgaccacag ctcagagcat gcgcacttat Protein function: Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation. Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle. Also acts as a negative regulator of angiogenesis (PubMed:17074759, PubMed:20516212, PubMed:22206000). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (PubMed:17074759, PubMed:22206000). While it activates CDKN1A in a DNA- dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells. [The UniProt Consortium]