MEOX1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 765 Sequence: atggatcccg cggccagcag ctgcatgagg agcctccagc ccccagcccc tgtctggggc tgccttcgaa acccccactc ggaaggcaat ggggcctcag ggctacccca ctacccgccc accccgttct ccttccacca gaaaccagac ttcctggcga cagcgacggc agcgtaccct gacttctcag cctcctgcct ggcagccacc ccacacagcc tgccccagga ggagcacatc ttcactgagc agcaccccgc tttcccacag tcccccaact ggcacttccc tgtctcagac gcccggcgca ggcccaactc aggcccggca gggggttcca aggaaatggg gaccagcagc ctgggcctgg tggacaccac aggaggccca ggcgatgact acggggtgct tgggagcact gccaatgaga cagagaagaa atcatccagg cggagaaagg agagttcaga caaccaggag aacagaggga agccggaggg cagcagcaaa gcccgcaagg agaggacggc cttcaccaag gagcagctgc gagagctgga ggcagagttt gcccatcata actacctgac tcggctccgc agatatgaga ttgcggtaaa cctggacctc tctgagcgcc aggtcaaagt gtggttccag aaccgaagga tgaagtggaa gcgtgtgaag ggaggtcagc ccatctcccc caatgggcag gaccctgagg atggggactc cacagcctct ccaagttcag Protein function: Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. [The UniProt Consortium]