MCF2L (Vector pUC, Accession No. BC020208)

Length: 2955 Sequence: atgacggtgc gccggctgtc actgctgtgc cgggacctct gggcgctgtg gctgctgctg aaggccggcg cagatgaaat catgcaccag gacatcgtcc cgctctgtgc tgccgacatc caggaccagc taaagaagcg ctttgcttac ctgtccggtg ggcgggggca ggacggaagc ccggttatca ccttccctga ctacccggcc ttcagcgaga ttccggacaa ggagttccag aatgtcatga cctacctcac cagcatcccc agcctgcagg acgctggcat cggattcatc ctggtgatag accggcgacg ggacaaatgg acctccgtga aggcgtccgt cctgcgcatc gcagcatctt tcccggcaaa cctgcagctc gtcctcgtgc ttcgcccgac gggttttttc caaaggactc tctccgacat cgctttcaaa ttcaatagag atgactttaa gatgaaggtg ccggtcataa tgctgagctc cgtaccagac ttacacggtt acatcgataa gtcgcagctg accgaggacc tgggtgggac cctggactac tgccactccc ggtggctgtg ccagcgcacg gccatcgaaa gtttcgccct catggtgaag cagacggctc agatgctgca gtccttcggg accgagctgg ctgaaacaga gctgcccaat gacgtccagt cgacaagctc agtgctgtgt gcgcacacag agaagaagga caaggcgaag gaggatttga ggctggcact gaaagagggg cacagtgtcc tggagagcct cagggagctg caggctgagg gctcagagcc cagtgtgaac caggaccagc ttgacaacca ggccaccgtg cagaggctcc tggcccagct gaacgaaacc gaggctgcct tcgatgagtt ctgggcaaag catcagcaga aactggagca gtgtctgcag ctccggcact ttgagcaggg cttccgggag gtcaaagcca tcttggacgc agcgtcccag aagatagcaa ccttcacaga catcggcaac agcctggcgc atgtggagca cctgctgagg gacctggcca gcttcgagga gaaatcaggc gtggccgtgg agagggcccg ggccctgtct ctggacggcg agcagctcat tgggaacaag cactacgcgg tagactccat ccgcccaaag tgccaggagc tccggcacct ctgtgaccag ttctctgcgg agatcgcaag gaggaggggg ctgctcagca agtccctgga gctgcaccgc cgcctggaga cgtccatgaa gtggtgtgat gaagggattt acctgctggc ctcacaacct gtggacaagt gccagtccca ggacggcgcg gaggctgccc tccaggaaat cgagaagttt ttggagaccg gtgcggaaaa taagatccag gagctcaacg cgatttacaa ggaatacgaa tccatcctca accaagatct catggagcac gtgcgaaagg tcttccagaa gcaggcaagc atggaggagg tgttccaccg caggcaggcc agcctgaaga agctggcggc caggcagacg cggcccgtgc agccggtggc ccccagaccc gaggcactgg caaagtcgcc ctgcccctcc ccaggcattc ggcgaggctc tgagaactcc agctccgagg gcggtgcgct ccggagaggg ccctaccgga gggccaagag tgagatgagt gagagccggc agggccgcgg ctcagcgggg gaggaggagg aaagcctggc catcctgcgc aggcacgtga tgagcgagct cctggacaca gaacgggcct acgtggagga gctgctgtgc gtcctggagg gctacgccgc ggagatggat aacccactga tggctcacct cctgtcaaca ggccttcaca acaagaagga tgttttgttt ggaaacatgg aggaaatcta tcacttccac aacaggatat tcctcaggga gctggaaaac tacactgact gcccagaact ggttggaaga tgctttctgg agaggatgga agatttccag atctatgaga agtactgtca gaacaagccc cgctctgaga gcctgtggag acagtgctcc gactgcccgt ttttccagga atgccagaga aagctggacc acaagctgag cctggactcc tacctgctga agccagtgca gaggatcacc aagtaccagc tgctgctcaa ggaaatgctg aaatacagca ggaactgcga gggggctgag gacctgcagg aggcgctgag ctccatcctg ggcatcctga aggccgtgaa cgactccatg cacctcatcg ctatcaccgg ctatgacggg aatctcggcg acctgggcaa gctgctgatg cagggctcgt tcagcgtctg gaccgaccac aagaggggcc acaccaaggt gaaggagctg gccaggttca agcccatgca gcggcacctg ttcctgcacg agaaggcagt gctcttctgc aagaagaggg aggagaatgg ggaggggtat gagaaagctc cctcctacag ctacaagcag tccttaaaca tggctgccgt tggcattacg gagaacgtga agggagatgc taagaagttc gagatctggt acaacgcgcg cgaggaggtc tacatcgtcc aggcgccaac tcctgagatt aaagccgcgt gggtgaatga aattcggaaa gtgctgacca gccagctgca ggcttgtaga gaagccagcc agcaccgggc gctggagcag tcacagagcc tgcccctgcc ggccccgacc agcaccagtc cctcaagagg aaactcaagg aacatcaaga agctggaaga aaggaaaaca gaccccctaa gcctggaggg atacgtcagc tcagcgccac tgacaaagcc ccccgaaaag ggcaaagagc Protein function: Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways. Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus. Isoform 5 activates CDC42 (PubMed:15157669). [The UniProt Consortium]