MBNL2 (Vector pENTR223.1, Accession No. BC104040)

Length: 1104 Sequence: ATGGCTTTGA ACGTTGCCCC AGTCAGAGAT ACAAAATGGC TGACATTAGA AGTCTGCAGA CAGTTTCAAA GAGGAACATG CTCACGCTCT GATGAAGAAT GCAAATTTGC TCATCCCCCC AAAAGTTGTC AGGTTGAAAA TGGAAGAGTA ATTGCCTGCT TTGATTCCCT AAAGGGCCGT TGTTCGAGAG AGAACTGCAA GTATCTTCAC CCTCCGACAC ACTTAAAAAC TCAACTAGAA ATTAATGGAA GGAACAATTT GATTCAGCAA AAAACTGCAG CAGCAATGCT TGCCCAGCAG ATGCAATTTA TGTTTCCAGG AACACCACTT CATCCAGTGC CCACTTTCCC TGTAGGTCCC GCGATAGGGA CAAATACGGC TATTAGCTTT GCTCCTTACC TAGCACCTGT AACCCCTGGA GTTGGGTTGG TCCCAACGGA AATTCTGCCC ACCACGCCTG TTATTGTTCC CGGAAGTCCA CCGGTCACTG TCCCGGGCTC AACTGCAACT CAGAAACTTC TCAGGACTGA CAAACTGGAG GTATGCAGGG AGTTCCAGCG AGGAAACTGT GCCCGGGGAG AGACCGACTG CCGCTTTGCA CACCCCGCAG ACAGCACCAT GATCGACACA AGTGACAACA CCGTAACCGT TTGTATGGAT TACATAAAGG GGCGTTGCAT GAGGGAGAAA TGCAAATATT TTCACCCTCC TGCACACTTG CAGGCCAAAA TCAAAGCTGC GCAGCACCAA GCCAACCAAG CTGCGGTGGC CGCCCAGGCA GCCGCGGCCG CGGCCACAGT CATGGCCTTT CCCCCTGGTG CTCTTCATCC TTTACCAAAG AGACAAGCAC TTGAAAAAAG CAATGGTACC AGCGCGGTCT TTAACCCCAG CGTCTTGCAC TACCAGCAGG CTCTCACCAG CGCACAGTTG CAGCAACACG CCGCGTTCAT TCCAACAGGG TCAGTTTTGT GCATGACACC CGCTACCAGT ATTGTACCCA TGATGCACAG CGCTACGTCC GCCACTGTCT CTGCAGCAAC AACTCCTGCA ACAAGTGTCC CCTTCGCAGC AACAGCCACA GCCAATCAGA TAATTCTGAA Protein function: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM). [The UniProt Consortium]