MAGT1 (Vector pENTR223.1, Accession No. BC060842)

Length: 1008 Sequence: atggcagcgc gttggcggtt ttggtgtgtc tctgtgacca tggtggtggc gctgctcatc gtttgcgacg ttccctcagc ctctgcccaa agaaagaagg agatggtgtt atctgaaaag gttagtcagc tgatggaatg gactaacaaa agacctgtaa taagaatgaa tggagacaag ttccgtcgcc ttgtgaaagc cccaccgaga aattactccg ttatcgtcat gttcactgct ctccaactgc atagacagtg tgtcgtttgc aagcaagctg atgaagaatt ccagatcctg gcaaactcct ggcgatactc cagtgcattc accaacagga tattttttgc catggtggat tttgatgaag gctctgatgt atttcagatg ctaaacatga attcagctcc aactttcatc aactttcctg caaaagggaa acccaaacgg ggtgatacat atgagttaca ggtgcggggt ttttcagctg agcagattgc ccggtggatc gccgacagaa ctgatgtcaa tattagagtg attagacccc caaattatgc tggtcccctt atgttgggat tgcttttggc tgttattggt ggacttgtgt atcttcgaag aagtaatatg gaatttctct ttaataaaac tggatgggct tttgcagctt tgtgttttgt gcttgctatg acatctggtc aaatgtggaa ccatataaga ggaccaccat atgcccataa gaatccccac acgggacatg tgaattatat ccatggaagc agtcaagccc agtttgtagc tgaaacacac attgttcttc tgtttaatgg tggagttacc ttaggaatgg tgcttttatg tgaagctgct acctctgaca tggatattgg aaagcgaaag ataatgtgtg tggctggtat tggacttgtt gtattattct tcagttggat gctctctatt tttagatcta aatatcatgg ctacccatac agctttctga Protein function: Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues, in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. [The UniProt Consortium]