MAGEA6 (Vector pUC, Accession No. BC041599)

Length: 945 Sequence: atgcctcttg agcagaggag tcagcactgc aagcctgaag aaggccttga ggcccgagga gaggccctgg gcctggtggg tgcgcaggct cctgctactg aggagcagga ggctgcctcc tcctcttcta ctctagttga agtcaccctg ggggaggtgc ctgctgccga gtcaccagat cctccccaga gtcctcaggg agcctccagc ctccccacta ccatgaacta ccctctctgg agccaatcct atgaggactc cagcaaccaa gaagaggagg ggccaagcac cttccctgac ctggagtctg agttccaagc agcactcagt aggaaggtgg ccaagttggt tcattttctg ctcctcaagt atcgagccag ggagccggtc acaaaggcag aaatgctggg gagtgtcgtc ggaaattggc agtacttctt tcctgtgatc ttcagcaaag cttccgattc cttgcagctg gtctttggca tcgagctgat ggaagtggac cccatcggcc acgtgtacat ctttgccacc tgcctgggcc tctcctacga tggcctgctg ggtgacaatc agatcatgcc caagacaggc ttcctgataa tcatcctggc cataatcgca aaagagggcg actgtgcccc tgaggagaaa atctgggagg agctgagtgt gttagaggtg tttgagggga gggaagacag tatcttcggg gatcccaaga agctgctcac ccaatatttc gtgcaggaaa actacctgga gtaccggcag gtccccggca gtgatcctgc atgctatgag ttcctgtggg gtccaagggc cctcattgaa accagctatg tgaaagtcct gcaccatatg gtaaagatca gtggaggacc tcgcatttcc tacccactcc tgcatgagtg ggctttgaga gagggggaag Protein function: Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. [The UniProt Consortium]