MAFG (Vector pUC, Accession No. BC012327)

Length: 489 Sequence: atgacgaccc ccaataaagg aaacaaggcc ttgaaggtga agcgggagcc gggtgagaat ggcaccagcc tgacggatga ggagctggtg accatgtcgg tgcgggagct gaaccagcac ctgcggggcc tgtccaagga ggagatcgtc cagctgaagc agcgccggcg cacgctcaag aaccgcggct acgctgccag ctgccgcgtg aagcgggtga cgcagaagga ggagctggag aagcagaagg cggagctgca gcaggaggtg gagaagctgg cctcagagaa cgccagcatg aagctggagc tcgacgcgct gcgctccaag tacgaggcgc tgcagacctt cgcccggacg gtggcccgca gccccgtggc gccagcccgg ggcccccttg ccgccggcct ggggcccctc gtcccaggca aggtggccgc caccagcgtc atcacaatag taaagtccaa gacggatgcc Protein function: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:11154691). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:8932385, PubMed:9421508, PubMed:11154691). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (PubMed:11154691). Transcription factor, component of erythroid- specific transcription factor NFE2L2 (PubMed:11154691). Activates globin gene expression when associated with NFE2L2 (PubMed:11154691). May be involved in signal transduction of extracellular H(+). [The UniProt Consortium]