LRWD1 (Vector pUC, Accession No. BC030547)

Length: 1944 Sequence: atgggccccc tctcggcgcg gctgctaatg cagcgcgggc gccccaagag cgaccggctg gggaagatcc ggagtctgga cctgtcagga ttggagctgc tttccgagca cctggacccc aaactcctgt gccgcctgac gcagctgcag gagcttgacc tgtctaacaa ccacctggag acgctgccgg acaacctggg cctgtcccac ctgcgtgtcc tccgctgcgc caacaaccag ctgggggatg ttactgcctt gtgccagttc cccaagctcg aggaactcag cctggagggc aaccccttcc tgacggtcaa tgacaacctg aaagtctcct ttctcctgcc cacgctccgt aaggtcaatg gcaaggatgc gtcctcaact tactctcagg tggagaacct gaatcgggag ctgaccagca gggtcacagc tcactgggag aagttcatgg ccacactggg tcctgaagag gaggctgaga aggcccaggc ggactttgtg aagtcggctg tcagggatgt ccgctacggg cccgagtccc tcagcgagtt cacccagtgg cgggtgcgga tgatctctga ggagctggtg gccgccagta ggacccaggt gcaaaaggct aacagcccag agaagccccc agaagctgga gctgcccaca agcccagggc cagactggcg gccttgaaac ggccagacga cgtcccactc agcctctctc ccagcaagcg ggcgtgtgcc tccccgtcgg cccaggtgga gggcagccct gtggcaggct ccgatggcag ccagcctgct gtgaagctgg agcccctgca cttcctgcag tgccacagca agaacaacag cccccaggac ctcgagaccc agctgtgggc ctgtgccttc gagccggcct gggaggaggg ggccacatcc cagaccgtgg ccacgtgcgg cggggaggct gtgtgcgtaa ttgattgcca gacgggcatc gtgctccaca agtacaaggc acccggcgag gagttctttt ctgtggcctg gaccgctctg atggtggtca cacaggctgg ccacaagaag cgctggagtg tgctggcggc tgcaggccta cggggcctgg tccggctgct gcacgtgcgt gccggcttct gctgcggggt catccgagcc cacaagaagg ccatcgccac cctgtgcttc agccccgccc acgagaccca tctcttcacg gcctcctatg acaagcggat catcctctgg gacatcgggg tgcccaacca ggactacgaa ttccaggcca gccagctgct cacactggac accacctcta tccccctgcg cctctgccct gtcgcctcct gcccggacgc ccgcctgctg gccggctgcg agggcggctg ctgctgctgg gacgtgcggc tggaccagcc ccaaaagagg agggtgtgtg aagtggaatt cgtcttctct gagggctccg aggcatctgg acggagagtg gatgggctgg catttgtgaa tgaggacatc gtggcctcca aggggagcgg cctgggcacc atctgcctgt ggagctggag gcagacgtgg gggggccggg gcagccagtc cacggtggca gtggtggtcc tggcgcggct gcaatggtcg tccaccgagt tggcctactt ctcgctcagc gcctgccctg ataaggggat tgtgctctgt ggggatgagg agggcaacgt gtggctctac gacgtcagca acatcctgaa gcagccaccc ctgctgccgg cagccctgca ggcccccaca cagatcctga agtggcccca gccctgggcc cttggccagg tggtgaccaa gaccatggtg aacacagtgg tggccaatgc ctccttcacc tacctcaccg ccctgacgga ctccaacatc gtagccatct gggggaggat Protein function: Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post- replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability. [The UniProt Consortium]