LNX1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 1899 Sequence: atgaaggcgc ttctgttgct ggtcttgcct tggctcagtc ctgctaacta cattgacaat gtgggcaacc tgcacttcct gtattcagaa ctctgtaaag gtgcctccca ctacggcctg accaaagata ggaagaggcg ctcacaagat ggctgtccag acggctgtgc gagcctcaca gccacggctc cctccccaga ggtttctgca gctgccacca tctccttaat gacagacgag cctggcctag acaaccctgc ctacgtgtcc tcggcagagg acgggcagcc agcaatcagc ccagtggact ctggccggag caaccgaact agggcacggc cctttgagag atccactatt agaagcagat catttaaaaa aataaatcga gctttgagtg ttcttcgaag gacaaagagc gggagtgcag ttgccaacca tgccgaccag ggcagggaaa attctgaaaa caccactgcc cctgaagtct ttccaaggtt gtaccacctg attccagatg gtgaaattac cagcatcaag atcaatcgag tagatcccag tgaaagcctc tctattaggc tggtgggagg tagcgaaacc ccactggtcc atatcattat ccaacacatt tatcgtgatg gggtgatcgc cagagacggc cggctactgc caggagacat cattctaaag gtcaacggga tggacatcag caatgtccct cacaactacg ctgtgcgtct cctgcggcag ccctgccagg tgctgtggct gactgtgatg cgtgaacaga agttccgcag caggaacaat ggacaggccc cggatgccta cagaccccga gatgacagct ttcatgtgat tctcaacaaa agtagccccg aggagcagct tggaataaaa ctggtgcgca aggtggatga gcctggggtt ttcatcttca atgtgctgga tggcggtgtg gcatatcgac atggtcagct tgaggagaat gaccgtgtgt tagccatcaa tggacatgat cttcgatatg gcagcccaga aagtgcggct catctgattc aggccagtga aagacgtgtt cacctcgtcg tgtcccgcca ggttcggcag cggagccctg acatctttca ggaagccggc tggaacagca atggcagctg gtccccaggg ccaggggaga ggagcaacac tcccaagccc ctccatccta caattacttg tcatgagaag gtggtaaata tccaaaaaga ccccggtgaa tctctcggca tgaccgtcgc agggggagca tcacatagag aatgggattt gcctatctat gtcatcagtg ttgagcccgg aggagtcata agcagagatg gaagaataaa aacaggtgac attttgttga atgtggatgg ggtcgaactg acagaggtca gccggagtga ggcagtggca ttattgaaaa gaacatcatc ctcgatagta ctcaaagctt tggaagtcaa agagtatgag ccccaggaag actgcagcag cccagcagcc ctggactcca accacaacat ggccccaccc agtgactggt ccccatcctg ggtcatgtgg ctggaattac cacggtgctt gtataactgt aaagatattg tattacgaag aaacacagct ggaagtctgg gcttctgcat tgtaggaggt tatgaagaat acaatggaaa caaacctttt ttcatcaaat ccattgttga aggaacacca gcatacaatg atggaagaat tagatgtggt gatattcttc ttgctgtcaa tggtagaagt acatcaggaa tgatacatgc ttgcttggca agactgctga aagaacttaa aggaagaatt actctaacta ttgtttcttg gcctggcact Protein function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. [The UniProt Consortium]