LNX1 (Vector pENTR223.1, Accession No. BC022983)

Length: 2187 Sequence: atgaaccagc cagagtctgc caacgatcct gaacccctgt gtgcagtgtg tggccaagcc cactccttgg aggaaaacca cttctacagc tatccagagg aagtggatga tgacctcatc tgccacatct gcctgcaggc tttgctggac cccctggaca ctccgtgtgg acacacctac tgcaccctct gcctcaccaa cttcctggtg gagaaggact tctgtcccat ggaccgcaag cctctggttc tgcagcactg caagaagtcc agcatcctgg tcaacaaact cctcaacaag ctactggtga cctgcccatt cagggagcac tgcacccagg tgttgcagcg ctgtgacctc gagcatcact ttcaaaccag ctgtaaaggt gcctcccact acggcctgac caaagatagg aagaggcgct cacaagatgg ctgtccagac ggctgtgcga gcctcacagc cacggctccc tccccagagg tttctgcagc tgccaccatc tccttaatga cagacgagcc tggcctagac aaccctgcct acgtgtcctc ggcagaggac gggcagccag caatcagccc agtggactct ggccggagca accgaactag ggcacggccc tttgagagat ccactattag aagcagatca tttaaaaaaa taaatcgagc tttgagtgtt cttcgaagga caaagagcgg gagtgcagtt gccaaccatg ccgaccaggg cagggaaaat tctgaaaaca ccactgcccc tgaagtcttt ccaaggttgt accacctgat tccagatggt gaaattacca gcatcaagat caatcgagta gatcccagtg aaagcctctc tattaggctg gtgggaggta gcgaaacccc actggtccat atcattatcc aacacattta tcgtgatggg gtgatcgcca gagacggccg gctactgcca ggagacatca ttctaaaggt caacgggatg gacatcagca atgtccctca caactacgct gtgcgtctcc tgcggcagcc ctgccaggtg ctgtggctga ctgtgatgcg tgaacagaag ttccgcagca ggaacaatgg acaggccccg gatgcctaca gaccccgaga tgacagcttt catgtgattc tcaacaaaag tagccccgag gagcagcttg gaataaaact ggtgcgcaag gtggatgagc ctggggtttt catcttcaat gtgctggatg gcggtgtggc atatcgacat ggtcagcttg aggagaatga ccgtgtgtta gccatcaatg gacatgatct tcgatatggc agcccagaaa gtgcggctca tctgattcag gccagtgaaa gacgtgttca cctcgtcgtg tcccgccagg ttcggcagcg gagccctgac atctttcagg aagccggctg gaacagcaat ggcagctggt ccccagggcc aggggagagg agcaacactc ccaagcccct ccatcctaca attacttgtc atgagaaggt ggtaaatatc caaaaagacc ccggtgaatc tctcggcatg accgtcgcag ggggagcatc acatagagaa tgggatttgc ctatctatgt catcagtgtt gagcccggag gagtcataag cagagatgga agaataaaaa caggtgacat tttgttgaat gtggatgggg tcgaactgac agaggtcagc cggagtgagg cagtggcatt attgaaaaga acatcatcct cgatagtact caaagctttg gaagtcaaag agtatgagcc ccaggaagac tgcagcagcc cagcagccct ggactccaac cacaacatgg ccccacccag tgactggtcc ccatcctggg tcatgtggct ggaattacca cggtgcttgt ataactgtaa agatattgta ttacgaagaa acacagctgg aagtctgggc ttctgcattg taggaggtta tgaagaatac aatggaaaca aacctttttt catcaaatcc attgttgaag gaacaccagc atacaatgat ggaagaatta gatgtggtga tattcttctt gctgtcaatg gtagaagtac atcaggaatg atacatgctt gcttggcaag actgctgaaa gaacttaaag gaagaattac tctaactatt gtttcttggc ctggcacttt Protein function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. [The UniProt Consortium]