LDLRAP1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 792 Sequence: atgctgttca gcctcaagta cctgggcatg acgctagtgg agcagcccaa gggtgaggag ctgtcggccg ccgccatcaa gaggatcgtg gctacagcta aggccagtgg gaagaagctg cagaaggtga ctctgaaggt gtcgccacgg ggaattatcc tgacagacaa cctcaccaac cagctcattg agaacgtgtc catatacagg atctcctatt gcacagcaga caagatgcac gacaaggtgt ttgcatacat cgcccagagc cagcacaacc agagcctcga gtgccacgcc ttcctctgca ccaagcggaa gatggcacag gctgttaccc tcaccgtagc ccaggccttc aaagtcgcct ttgagttttg gcaggtgtcc aaggaagaga aagagaagag ggacaaagcc agccaagagg gaggggacgt cctgggggcc cgccaagact gcaccccccc cttgaagagc ttggtcgcca ctgggaacct gctggactta gaggagacgg ctaaggcccc gctgtccacg gtcagcgcca acaccaccaa catggacgag gtgccgcggc cacaagcctt gagtggcagc agtgttgtct gggagctgga tgatggcctg gatgaagcgt tttcgaggct tgcccagtct cggacaaacc ctcaggtcct ggacactggc ctgacagccc aggacatgca ttacgcccag tgcctctcgc ctgtcgactg ggacaagcct gacagcagcg gcacagagca ggatgacctc ttcagcttct Protein function: Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non- polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression. [The UniProt Consortium]