LBR (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, Ac

Length: 1848 Sequence: atgccaagta ggaaatttgc cgatggtgaa gtggtaagag gtcgatggcc tgggagttca ctttattatg aagtagaaat tctgagccac gacagcacct cccagcttta cactgtgaag tataaagatg gaacagagct tgaattgaaa gagaatgata ttaagccttt aacttccttt aggcaaagga aaggtggctc aacttccagt tccccttcca gacgccgagg gagtcgatca aggtcacgct cccgatcccc tggtcgacca cctaaaagtg cccgccgatc tgcttctgct tcccaccagg ccgacattaa ggaagcaagg agggaagtgg aagttaaatt gactccgctg attctgaagc catttggaaa tagcatcagc agatataatg gggagcctga gcatattgag agaaatgacg cacctcataa aaatacacag gaaaaattca gtttgtcaca agaaagcagt tacatagcaa cacagtatag ccttcgtcca agaagagaag aagtcaaatt aaaagaaata gattctaagg aagaaaaata cgttgcaaaa gaactggcag tgagaacctt tgaagtgacc cccatccggg caaaggactt ggagtttgga ggagtacctg gtgtgtttct catcatgttt ggcctgcctg tgttcctctt cctgttgctg ttgatgtgta aacagaaaga tcccagtctt ctgaatttcc ctcctccttt gccagctttg tatgagttat gggaaaccag agtatttggg gtctacctcc tgtggttttt gattcaagtc ctgttctacc tactgccaat tggaaaggtt gtagaaggaa cgcctcttat tgatggaaga agactcaagt atagattaaa tggattctat gcttttatcc tgacatctgc agtcatcgga acatctctct tccagggcgt agagtttcat tacgtgtaca gtcattttct tcagtttgca cttgcggcca ctgttttttg tgtggtcttg agtgtgtatc tctacatgcg ctctttgaaa gcgccccgga atgacctgtc gcctgccagc tctggaaatg ctgtctatga tttcttcatt ggccgtgaat taaaccctcg aattggtact tttgatctca aatacttttg tgaattgcgc cccggattga ttggatgggt ggttattaac ttggtgatgc ttttggctga aatgaaaata caggaccgcg ctgttccatc cttggccatg attttagtta atagtttcca gcttctctat gtggtggatg ctctctggaa tgaggaagcg ttgttgacga ccatggacat catccacgat ggatttggat tcatgctggc ttttggagac ttggtgtggg ttccctttat ttacagcttc caagcctttt atttagtcag tcatccaaat gaagtgtctt ggccaatggc ttctctaatt attgttctga aactttgtgg ttatgtaatc ttccgaggtg caaattctca gaaaaatgca ttccggaaaa atcccagtga tccaaagctt gcacatttaa aaaccattca tacttcaacg ggaaaaaatc ttctagtttc tggatggtgg ggctttgttc gccaccccaa ttacttgggt gatctcatca tggccttggc gtggtccctc ccatgtggtt ttaaccacat tctgccttat ttctacataa tttatttcac catgttgctt gtccaccgag aagctcgtga cgagtaccac tgtaagaaga aatacggcgt ggcttgggaa aagtactgtc agcgtgtgcc ctaccgtata tttccataca Protein function: Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:9630650, PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation. Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation. Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). [The UniProt Consortium]