KPNA6 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1611 Sequence: atggagacca tggcgagccc agggaaagac aattatcgaa tgaagagcta taagaacaat gctctaaacc ctgaagaaat gagacgaaga agagaggaag agggcattca gctccggaag cagaagcgag agcaacaact ttttaaacgg agaaatgtgg agctgattaa tgaagaagct gccatgttcg atagtcttct catggactct tatgtgagct ctaccactgg ggagagtgtg atcacaagag agatggtgga gatgctcttt tctgatgatt ctgacctgca gttagcaacc acacagaaat tccggaaact gctctccaaa gagcctagtc ctccaataga tgaagttatc aacactccaa gagtggtgga tcggttcgtg gagtttctga agaggaatga gaattgtaca ttacagtttg aagctgcctg ggctctaacg aatattgcct ctggaacctc tcagcagacc aaaattgtca ttgaagcagg ggctgtcccc atttttatag agctgcttaa ttcagacttt gaggatgttc aggaacaggc agtctgggca ctgggaaaca tagctggaga tagctctgtt tgccgagatt acgtcttgaa ctgttccatc cttaatcctt tgttaacact ccttaccaag tccacacgac tgacgatgac acggaatgca gtctgggccc tgtcaaatct ctgccgaggg aaaaacccac ccccagagtt tgcaaaggtc tctccttgtt tgcctgtact gtctcgccta ctcttcagca gcgactcgga cttgctggca gatgcttgct gggccctttc ttatctgtct gatggcccca atgagaagat ccaggcagtc atagactccg gagtctgccg gagattggta gagctgctga tgcacaatga ttacaaagtg gcttctcctg ccctgagagc cgtgggtaac atcgtcactg gggatgacat ccagacccag gtcattctta actgttcagc cctaccttgc cttctccact tgttgagcag tcccaaggag tcaatccgga aggaagcttg ctggactatt tcaaatatta ctgctggcaa cagggctcaa atacaggctg ttatagatgc aaatatcttc cctgtgttga tcgaaatcct tcagaaagca gagtttcgta caaggaaaga ggcagcctgg gccatcacca atgccacatc aggaggaacc cctgagcaga tcaggtacct ggtctcactg ggctgcatca aacccctatg tgacttgctg actgtaatgg attcgaagat tgtgcaagtg gccctcaatg gactggagaa catcctgcgg cttggagagc aagagggcaa gcgcagtggc tcaggggtca atccttattg tggcctcata gaggaagcct atggcttgga taaaattgag tttctccaga gccacgagaa ccaggagatc taccagaagg ccttcgacct cattgagcac tactttggtg tagaagacga tgatagcagc ctggctcccc aagtcgatga aacgcaacag cagttcatct tccagcagcc tgaggccccc atggagggct tccagctata Protein function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [The UniProt Consortium]