KPNA5 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1620 Sequence: atggatgcca tggctagtcc agggaaagat aactatagaa tgaaaagtta taagaataaa gccctaaatc ctcaagagat gcgtagacga agagaagaag aaggaataca gcttagaaaa caaaaaagag aagaacagtt gttcaaacgc agaaatgtct atttgcccag aaatgatgaa tctatgcttg aaagtcctat acaggatcca gatattagtt ccactgtacc cattccagag gaagaagttg ttactacaga tatggttcag atgatttttt ctaataatgc tgatcaacag ctaacagcaa cacagaaatt tagaaagctg ctttctaaag aacctaatcc accaatagat caagttatac agaaaccagg agttgtacag agatttgtga aatttcttga aagaaatgaa aattgcactt tacaatttga agctgcatgg gcattaacaa atatagcatc tggaactttt ctgcatacca aggtagtgat tgaaactggg gctgttccga tttttatcaa acttcttaat tctgaacatg aagatgttca ggaacaggct gtttgggcac ttggtaatat tgctggtgac aatgcagaat gcagagattt tgttttgaat tgtgaaatac ttccacctct tttagagtta ttaacaaatt caaacagact cacaacaaca agaaatgccg tgtgggccct ctcaaattta tgtagaggca aaaaccctcc tccaaacttt agtaaggttt caccttgctt aaatgtcctg tcacgactgt tgtttagcag tgacccagat gtgttagcag acgtgtgttg ggccctttct tatctctccg atggacccaa tgataaaatt caagcagtca ttgattctgg agtctgtcga agattggtgg aacttttgat gcacaatgat tataaagttg tatcacctgc attaagggca gttggtaata ttgtgactgg tgatgatatt caaacacagg taattttgaa ttgttctgca ttaccctgtc tcttacattt attgagtagc ccaaaggagt caattagaaa agaagcctgc tggactgttt ctaacatcac tgctggaaat agagctcaga ttcaggctgt tatagatgca aatatttttc ctgttttgat tgagattctt cagaaagcag agtttcgtac cagaaaagaa gcagcttggg ctataactaa tgcaacatca ggaggtactc cagagcaaat aaggtatttg gtagctttag gctgcattaa accactttgt gatcttttga ctgttatgga ctccaaaata gtccaagtgg ctttaaatgg acttgaaaat attttacgtc ttggagaaca agaatctaag cagaatggaa taggcattaa tccatactgt gctctcattg aagaagcata tggtctggat aaaattgagt ttttgcaaag ccatgaaaat caggaaattt accagaaggc atttgatctg attgaacatt actttggtgt agaagaagat gaccccagca ttgtacctca ggtggatgaa aaccaacaac agtttatatt tcagcagcag gaagcaccaa tggatggatt Protein function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. [The UniProt Consortium]