KLHL21 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1794 Sequence: ATGGAGCGAC CGGCGCCCCT GGCCGTGCTT CCCTTCTCGG ACCCCGCGCA CGCCCTGAGC CTGCTGCGCG GCCTGAGCCA GCTGCGCGCC GAGCGCAAGT TCCTGGACGT GACCCTGGAG GCGGCGGGCG GGCGCGACTT CCCGGCGCAC CGTGCGGTGC TGGCCGCCGC CAGCCCCTAC TTCCGCGCCA TGTTCGCGGG GCAGCTGCGC GAGAGCCGCG CCGAGCGGGT GCGCCTGCAC GGAGTGCCTC CCGACATGCT GCAGCTGCTG CTGGACTTCA GCTACACGGG CCGCGTGGCG GTAAGCGGCG ACAACGCTGA GCCGCTGCTG CGCGCCGCCG ACCTGCTGCA GTTCCCGGCC GTGAAGGAGG CGTGCGGGGC CTTCCTGCAG CAGCAGCTCG ACCTGGCCAA CTGCCTGGAC ATGCAGGACT TCGCTGAGGC CTTCAGCTGC TCGGGACTGG CGAGCGCGGC GCAGCGGTTC ATTCTGCGCC ACGTGGGCGA GCTGGGCGCC GAGCAGCTGG AGCGGCTGCC ACTGGCGCGC CTGCTGCGCT ACCTGCGGGA CGACGGGCTG TGTGTGCCCA AGGAGGAGGC CGCCTACCAG CTGGCGCTGC GCTGGGTCCG CGCTGACCCG CCGCGCCGCG CCGCGCACTG GCCGCAGCTG CTGGAGGCCG TGCGCCTGCC CTTCGTGCGC CGCTTCTACC TGTTGGCGCA CGTCGAGGCC GAGCCGCTGG TGGCGCGCTG CCCACCCTGC CTGCGCCTGC TGCGCGAGGC GCGCGACTTC CAGGCGGCGC GCTACGACCG CCACGACCGC GGGCCCTGTC CCCGAATGCG TCCTCGCCCG TCCACCGGTC TCGCCGAGAT CCTCGTGCTC GTGGGCGGCT GCGACCAGGA CTGTGACGAG CTGGTCACTG TCGACTGCTA CAACCCGCAG ACGGGTCAGT GGCGCTACCT GGCCGAGTTC CCAGACCACC TGGGCGGAGG CTACAGCATC GTGGCGCTGG GCAATGACAT CTACGTGACG GGTGGGTCCG ATGGCTCCCG GCTCTATGAC TGCGTGTGGA GGTACAACTC AAGCGTGAAT GAGTGGGCGG AGGTGGCGCC CATGCTGAAG GCCCGCGAGT ACCACAGCTC CTCTGTGCTG GACGGACTGC TGTACGTGGT GGCCGCCGAC AGCACCGAGC GCTATGACCA CACCACTGAC TCCTGGGAGG CCCTGCAGCC CATGACCTAC CCCATGGACA ACTGCTCCAC CACTGCGTGC CGTGGCCGGC TCTATGCCAT CGGCTCCCTG GCTGGCAAGG AGACCATGGT GATGCAGTGC TACGACCCGG ACACCGACCT GTGGTCGCTG GTGGACTGCG GCCAGCTCCC GCCCTGGTCC TTCGCCCCCA AGACTGCGAC TCTAAACGGA CTCATGTACT TTGTCAGGGA TGACTCCGCT GAGGTGGACG TGTACAACCC GACGAGGAAC GAATGGGACA AGATCCCGTC CATGAATCAG GTACATGTGG GGGGCAGCCT GGCCGTCCTT GGGGGGAAGC TGTACGTCTC TGGGGGATAC GACAATACAT TTGAACTCTC GGACGTGGTA GAGGCCTATG ACCCAGAGAC TCGCGCGTGG AGCGTGGTGG GGCGGCTCCC AGAACCCACC TTCTGGCATG GCAGTGTCAG CATCTTCCGC CAGTTCATGC CCCAGACCTT CTCGGGTGGG CGTGGCTTCG AGTTGGACAG TGGCAGCGAT GACATGGACC CAGGCCGACC CCGGCCGCCG CGGGACCCCG ATGAGCTGCA Protein function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome. [The UniProt Consortium]