KIAA1598 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pU

Length: 378 Sequence: atgccagtgt tgggttctgt atccagtgta acaaaaacag ccttgaacaa gaaaactctg gaggcagaat tcaacagccc gtccccccca acacctgagc caggtgaagg gccccgtaaa ttggaaggat gcacaagttc caaggttacg tttcagcctc ccagtagcat tggatgcagg aaaaaataca ttgacggtga aaaacaagcc gaaccagttg tagttttaga tcctgtttct acacatgaac cccaaaccaa agaccaggtt gctgaaaaag atccaactca acacaaggag gatgaaggcg aaattcaacc agaaaacaaa gaagacagca ttgaaaacgt gagagagaca gacagctcca Protein function: Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1- dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. [The UniProt Consortium]