KIAA0196 (Vector pUC, Accession No. BC026951)

Length: 3480 Sequence: atgttggact ttctagctga gaacaacctc tgtggccaag caatcctaag gattgtttcc tgtggtaatg ccatcattgc tgaacttttg agactctctg agtttattcc tgctgtgttc aggttaaaag acagagctga tcaacagaaa tatggagata tcatatttga tttcagctat tttaagggtc cagaattatg ggaaagcaaa ctggatgcta agccagagct acaggattta gatgaagaat ttcgtgaaaa caacatagaa attgtgacca gattttattt agcatttcaa agtgtacata aatatattgt agacttaaac agatatctag atgatctcaa tgaaggggtt tatattcagc aaaccttaga aactgtgctt ctcaatgaag atggaaaaca acttctatgt gaagcactgt acttatatgg agttatgcta ctggtcattg accaaaagat tgaaggagaa gtcagagaga ggatgctggt ttcttactac cgatacagtg ctgctcgatc ttctgctgat tcaaatatgg acgatatttg taagctgctt cgaagtacag gttattctag ccaaccaggt gccaaaagac catccaacta tcccgagagc tatttccaga gagtgcctat caacgaatcc ttcatcagta tggtcattgg tcgacggaga tctgatgata tttacaacca ggtctcagcg tatcctttgc cggagcatcg cagcacagcc ctggcaaacc aagctgccat gctgtacgtg attctctact ttgagccttc catccttcac acccatcaag caaaaatgag agagatagtg gataaatact ttccagataa ttgggtaatt agtatttaca tggggatcac agttaatcta gtagatgctt gggaacctta caaagctgca aaaactgctt taaataatac cctggacctt tcaaatgtca gagaacaggc aagcagatat gctactgtca gtgaaagagt gcatgctcaa gtgcagcaat ttctaaaaga aggttattta agggaggaga tggttctgga caatatccca aagcttctga actgcctgag agactgcaat gttgccatcc gatggctgat gcttcataca gcagactcag cctgtgaccc aaacaacaaa cgccttcgtc aaatcaagga ccagattcta acagactctc ggtacaatcc caggatcctc ttccagctgc tgttagatac tgcacaattt gagtttatac tcaaagagat gttcaagcaa atgctttcag aaaagcaaac caaatgggag cattacaaga aagagggttc ggagcggatg actgagcttg ctgatgtctt ttcaggagtg aaacccctaa ccagagtgga gaaaaatgaa aaccttcaag cttggttcag agagatctca aaacaaatat tgtctttaaa ttatgatgat tctactgctg cgggcagaaa aactgtacaa ctgatacaag ctttggaaga ggttcaagaa ttccaccagt tggaatccaa tctgcaagta tgtcagtttc ttgccgatac tcgaaagttt cttcatcaaa tgatcagaac cattaacatt aaagaggagg ttctgatcac aatgcagatc gttggggacc tttctttcgc ttggcagttg attgacagtt tcacatccat catgcaagaa agcataaggg taaatccatc catggttact aaactcagag ctaccttcct aaagcttgcc tctgccctcg atctgcccct tcttcgtatt aatcaggcaa atagccccga cctgctcagc gtgtcacagt actattctgg agagttggta tcctatgtga gaaaagtttt gcagatcatc ccagaaagca tgtttacatc tcttctaaag atcataaagc ttcagaccca cgacattatt gaagtgccta cccgcctgga caaagacaag ctgagggact atgctcagct aggcccacga tacgaggttg ccaagcttac tcatgctatt tccattttta ctgaaggcat cttaatgatg aaaacgactt tggttggcat catcaaggtg gatccaaagc agttgctgga agatggaata aggaaagagc ttgtgaagcg cgttgccttt gccctgcata ggggactgat attcaaccct cgagccaagc caagtgaatt gatgcccaag ctgaaagagt tgggagcgac catggatgga ttccatcgtt cttttgaata catacaggac tatgtcaaca tttatggtct gaagatttgg caggaagaag tatctcgtat cataaattac aacgtggagc aagagtgtaa taactttcta agaacgaaga ttcaagattg gcaaagcatg taccagtcca ctcatattcc aatacccaag tttacccctg tggatgagtc tgtaacgttt attggtcgac tctgcagaga aatcctgcgg atcacagacc caaaaatgac atgtcacata gaccagctga acacttggta tgatatgaaa actcatcagg aagtgaccag cagccgcctc ttctcagaaa tccagaccac cttgggaacc tttggtctaa atggcttaga caggcttctg tgctttatga ttgtaaaaga gttacagaat ttcctcagta tgtttcagaa aattatcctg agagacagaa ctgttcagga cactttaaaa accctcatga atgctgtcag tcccctaaaa agtattgtcg caaattcaaa taaaatttat ttttccgcca ttgccaaaac acagaagatt tggactgcgt atctcgaggc tataatgaag gttgggcaga tgcagattct gagacaacag attgccaatg aattaaatta ttcttgtcgg tttgattcta aacatctggc agctgctctg gagaatctca ataaggctct cctagcagac attgaagccc actatcagga cccttcactt ccttacccca aagaagataa cacactttta tatgaaatca cagcctatct ggaggcagct ggcattcaca acccactgaa taagatatac ataacaacaa agcgcttacc ctattttcca attgtaaact ttctattttt gatcgctcag ttgccaaaac ttcaatacaa caaaaatctg ggaatggtct gccgaaaacc gaccgacccg gttgattggc caccacttgt cctgggactg ctcactctgc tgaagcagtt ccattcccgg tacaccgagc agttcctggc gctgattggc cagtttatct gctccacggt ggagcagtgt acaagccaga agatacctga aattcctgca gatgttgtgg gtgcccttct gttcctggag gattatgttc ggtacacaaa gctacccagg agggttgctg aagcacatgt gcctaatttc atttttgatg agttcagaac Protein function: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093). May be involved in axonal outgrowth. Involved in cellular localization of ADRB2 (PubMed:23085491). Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (PubMed:23676666). [The UniProt Consortium]