KIAA0141 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pU

Length: 1548 Sequence: atgtggcgcc tcccgggact cctgggccga gctcttcccc gtacactggg acctagcctc tggagggtga ctcctaagtc caccagccca gatgggcctc agactacctc ctccactttg ctggttcctg tgcctaacct cgacaggtca ggtccccatg gcccaggcac gagcgggggt ccaaggtccc atggatggaa ggatgccttc caatggatgt cttcccgtgt ctccccgaac accctatggg atgccatatc ttggggcact ctggccgtgc tggccctgca gctggcaagg cagatccact tccaggcatc cctgccagca ggacctcagc gggtagaaca ctgctcctgg cacagtcccc tggaccgttt cttctcatct cccttgtggc acccatgctc ctcactgcga caacacatcc tccccagccc cgatggccca gctcccaggc acactggcct cagggaaccc aggcttggcc aggaagaagc ctcagctcag ccccggaact tctcacacaa ctctttgaga ggagctcgtc ctcaggaccc ctctgaggaa ggtcccggtg attttggctt cctgcatgcc agtagtagca tcgagtccga ggcaaaacca gcccagcctc agcccactgg tgaaaaggaa caagataaat caaaaactct ttcccttgag gaggctgtga cttccattca gcagctcttc cagctcagtg tttccatcac tttcaacttc ctgggaacag agaacatgaa gagtggcgac cacacggcag ccttttctta cttccagaaa gctgcagccc gcggctacag caaagcgcag tacaatgcgg gcttgtgtca tgagcatggc agaggcaccc ccagggacat tagcaaggcg gtcctttatt atcagttggc tgccagccag ggccacagcc tggctcagta ccgctatgcc aggtgcctac tacgagaccc agcctcttcg tggaaccctg agcggcagag ggcagtgtcc ttgctgaagc aggctgcaga ctcaggcttg agagaggccc aagctttcct cggggtgctt ttcaccaagg agccctacct ggatgagcag agagctgtga aatatctttg gcttgcagcc aacaatgggg actcacagag caggtaccac cttggaattt gctatgagaa aggccttggt gtgcagagga atctgggaga ggccttgaga tgttaccagc agtcagccgc tctgggaaat gaggccgccc aggagaggct gcgagccctc ttttccatgg gggctgcagc cccggggccc agcgacctga cagttacagg actgaagtct ttctccagcc cctccctctg cagcttgaac accctgctag caggaacctc acgcctacca catgcctcga gcacaggcaa ccttggcctc ctctgcagaa gtgggcatct cggagccagc ctggaagcct ccagcagggc tattccccca cacccctacc cactggaaag gagtgttgta agactaggtt Protein function: [DAP3-binding cell death enhancer 1]: Key activator of the integrated stress response (ISR) following mitochondrial stress (PubMed:32132706, PubMed:32132707). In response to mitochondrial stress, cleaved by the protease OMA1, generating the DAP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR (PubMed:32132706, PubMed:32132707). Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation (PubMed:20563667). [The UniProt Consortium]