KCTD6 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 714 Sequence: atggataatg gagactgggg ctatatgatg actgacccag tcacattaaa tgtaggtgga cacttgtata caacgtctct caccacattg acgcgttacc cggattccat gcttggagct atgtttgggg gggacttccc cacagctcga gaccctcaag gcaattactt tattgatcga gatggacctc ttttccgata tgtcctcaac ttcttaagaa cttcagaatt gaccttaccg ttggatttta aggaatttga tctgcttcgg aaagaagcag atttttacca gattgagccc ttgattcagt gtctcaatga tcctaagcct ttgtatccca tggatacttt tgaagaagtt gtggagctgt ctagtactcg gaagctttct aagtactcca acccagtggc tgtcatcata acgcaactaa ccatcaccac taaggtccat tccttactag aaggcatctc aaattatttt accaagtgga ataagcacat gatggacacc agagactgcc aggtttcctt tacttttgga ccctgtgatt atcaccagga agtttctctt agggtccacc tgatggaata cattacaaaa caaggtttca cgatccgcaa cacccgggtg catcacatga gtgagcgggc caatgaaaac acagtggagc acaactggac tttctgtagg ctagcccgga agacagacga Protein function: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1, the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1, the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887). [The UniProt Consortium]