KCTD17 (Vector pUC, Accession No. BC031038)

Length: 945 Sequence: atgaggatgg aggccgggga ggcagcgccg ccggcggggg cgggcggccg cgccgcaggc ggctggggca agtgggtgcg gctcaacgtg gggggcacgg tgttcctgac cacccggcag acgctgtgcg gcgagcagaa gtccttcctc agccgcctgt gccaggggga agagctgcag tcggaccggg atgagaccgg ggcctacctc attgaccgtg accccaccta cttcgggccc atcctgaact tcctccggca tggcaagctg gtgctggaca aggacatggc tgaggagggg gtcctggagg aagccgagtt ctacaacatc ggcccgctga tccgcatcat caaagaccgg atggaagaga aggactacac ggtcacccag gtcccaccca agcatgtgta ccgcgtgctg cagtgccagg aggaggagct cacgcaaatg gtctcaacca tgtctgatgg ctggcgcttc gagcagctgg tgaacatcgg ctcgtcctac aactacggca gcgaggacca ggcagagttc ctgtgtgtgg tgtccaagga gctccacagc accccaaacg ggctgagctc agagtccagc cgcaaaacca agagcacgga ggagcagctg gaggagcagc agcagcagga ggaggaggtg gaggaggtgg aggtggaaca ggtgcaggtg gaggcagatg cacaggagaa agcccagtca tctcaggatc ccgctaacct tttctccctc ccaccactgc ctcctcctcc gcttcccgct ggaggttccc gtccgcaccc tctcagacct gaggctgagc ttgcagtgag ggcttctcct cggcccctcg cccgccccca gagctgccat ccctgctgtt acaagccaga ggcacccgga tgtgaggccc cagatcacct ccagggactt ggggttccca Protein function: Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. It acts as a substrate- adapter for CUL3-RING ubiquitin ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation (PubMed:25270598). May be involved in endoplasmic reticulum calcium ion homeostasis (PubMed:25983243). [The UniProt Consortium]