KCTD17 (Vector pUC, Accession No. BC009961)

Length: 744 Sequence: atgaggatgg aggccgggga ggcagcgccg ccggcggggg cgggcggccg cgccacaggc ggctggggca agtgggtgcg gctcaacgtg gggggcacgg tgttcctgac cacccggcag acgctgtgcc gcgagcagaa gtccttcctc agccgcctgt gccaggggga agagctgcag tcggaccggg atgagaccgg ggcctacctc attgaccgtg accccaccta cttcgggccc atcctgaact tcctccggca tggcaagctg gtgctggaca aggacatggc tgaggagggg gtcctggagg aagccgagtt ctacaacatc ggcccgctga tccgcatcat caaagaccgg atggaagaga aggactacac ggtcacccag gtcccaccca agcacgtgta ccgcgtgctg cagtgccagg aggaggagct cacgcaaatg gtctccacca tgtctgatgg ctggcgcttc gagcagctgg tgaacatcgg ctcctcctac aactacggca gcgaggacca ggcagagttc ctgtgtgtgg tgtccaagga gctccacagc accccaaacg ggctgagctc agagtccagc cgcaaaacca agagcacgga ggagcagctg gaggagcagc agcagcagga ggaggaggtg gaggaggtgg aggtggaaca ggtgcaggtg gaggcagatg cacaggagaa aggtgcagcc aacccccagg aggatgattg Protein function: Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. It acts as a substrate- adapter for CUL3-RING ubiquitin ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation (PubMed:25270598). May be involved in endoplasmic reticulum calcium ion homeostasis (PubMed:25983243). [The UniProt Consortium]