KCNMB1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 393 Sequence: atggtgaaga agctggtgat ggcccagaag cggggagaga cacgagccct ttgcctgggt gtaaccatgg tggtgtgtgc cgtcatcacc tactacatcc tggtcacgac tgtgctgccc ctctaccaga aaagcgtgtg gacccaggaa tccaagtgcc acctgattga gaccaacatc agggaccagg aggagctgaa gggcaagaag gtgccccagt acccatgcct gtgggtcaac gtgtcagctg ccggcaggtg ggctgtgctg taccacacgg aggacactcg ggaccagaac cagcaggtac tgaactggag ggatggggac acatcccttt atccctgtca ggtgtgtgag cctgttccta actgtccctg tccccgaggc Protein function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate. [The UniProt Consortium]