KCNAB2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1104 Sequence: atgtatccag aatcaacgac gggctccccg gctcggctct cgctgcggca gacgggctcc cccgggatga tctacagtac tcggtatggg agtcccaaaa gacagctcca gttttacagg aacctgggca agtctggcct gcgggtctcc tgcctgggac ttggaacatg ggtgaccttc ggaggccaga tcaccgatga gatggcagag cagctcatga ccttggccta tgataatggc atcaacctct tcgatacagc agaagtctac gcagccggca aggctgaagt ggtactggga aacatcatta agaagaaagg atggaggcgg tccagcctcg tcatcaccac caagatcttc tggggcggaa aggcggagac ggagcggggc ctgtccagga agcacataat cgaaggtctg aaagcttccc tggagcgact gcagctggag tacgtggatg tggtgtttgc caaccgcccg gaccccaaca ccccgatgga agagaccgtc cgcgccatga cccacgtcat caaccagggg atggccatgt actggggcac gtcacgctgg agctccatgg agatcatgga ggcctactcc gtggcccggc agttcaacct gaccccgccc atctgcgagc aggctgagta ccacatgttc cagcgtgaga aagtggaggt gcagctgccg gagctgttcc acaagatagg agtgggcgcc atgacctggt cccctctggc ctgtggcatt gtttctggca agtacgacag tggcatccca ccctactcaa gagcctcctt gaagggctac cagtggctga aggacaagat cctcagtgag gagggccggc gccagcaagc caagctgaag gagctgcagg ccatcgccga gcgcctgggc tgcaccctgc cccagctggc catagcctgg tgcctgagga atgagggagt cagctccgtg ctcctggggg cctccaatgc ggaccagctc atggagaaca ttggggcaat acaggtcctt ccgaaactgt cgtcttccat tatccacgag attgatagta ttttgggcaa taaaccctac agcaaaaagg actacagatc Protein function: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7649300, PubMed:11825900). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability. Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity. Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:7649300, PubMed:11825900). Promotes KCNA4 channel closure (PubMed:7649300, PubMed:11825900). Modulates the functional properties of KCNA5. Enhances KCNB2 channel activity. Binds NADPH and has NADPH- dependent aldoketoreductase activity. Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4- nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro). [The UniProt Consortium]