KCNAB1 (Vector pENTR223.1, Accession No. BC043166)

Length: 1206 Sequence: atgcaagtct ccatagcctg cacagagcac aatttgaaga gtcggaatgg tgaggaccga cttctgagca agcagagctc caccgccccc aatgtggtaa acgcagcccg ggccaaattc cgcacggtcg ctatcatcgc gcgcagcctg gggacgttca cgcctcagca tcacatttct ctcaaagagt ccaccgcaaa gcagactggc atgaaatata ggaatcttgg aaaatcagga ctcagagttt cttgcttggg tcttggaaca tgggtgacat ttggaggtca aatttcagat gaggttgctg aacggctgat gaccatcgcc tatgaaagtg gtgttaacct ctttgatact gccgaagtct atgctgctgg aaaggctgaa gtgattctgg ggagcatcat caagaagaaa ggctggagga ggtccagtct ggtcataaca accaaactct actggggtgg aaaagctgaa acagaaagag ggctgtcaag aaagcatatt attgaaggat tgaagggctc cctccagagg ctgcagctcg agtatgtgga tgtggtcttt gcaaatcgac cggacagtaa cactcccatg gaagaaattg tccgagccat gacacatgtg ataaaccaag gcatggcgat gtactggggc acctcgagat ggagtgctat ggagatcatg gaagcctatt ctgtagcaag acagttcaat atgatcccac cggtctgtga acaagctgag taccatcttt tccagagaga gaaagtggag gtccagctgc cagagctcta ccacaaaata ggtgttggcg caatgacatg gtctccactt gcctgtggaa tcatctcagg aaaatacgga aacggggtgc ctgaaagttc cagggcttca ctgaagtgct accagtggtt gaaagaaaga attgtaagtg aagaagggag aaaacagcaa aacaagctaa aagacctttc cccaattgcg gagcgtctgg gatgcacact acctcagcta gctgttgcgt ggtgcctgag aaacgaaggt gtgagttctg tgctcctggg atcatccact cctgaacaac tcattgaaaa ccttggtgcc attcaggttc tcccaaagat gacatcacat gtggtaaatg agattgataa catactgcgc aacaagccct acagcaagaa ggactataga Protein function: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits. Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity. Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6. Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity. Binds NADPH, this is required for efficient down- regulation of potassium channel activity (PubMed:17540341). Has NADPH- dependent aldoketoreductase activity. Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity. [The UniProt Consortium]