JMY (Vector pUC, Accession No. BC130624)

Length: 1869 Sequence: atggtggagc ttctggactt gtatcagatg gaggatgaag cctacagcag ccttgcagaa gctacaaccg aactctatca gtatttacta cagccattcc gagacatgag agaacttgcc atgctacgaa gacagcagat caagatttcc atggagaatg attatctggg acctcgaaga attgagagtc tacaaaaaga agatgctgat tggcagcgga aagctcacat ggctgtactg tctattcaag atcttactgt caagtacttt gaaataacag ctaaagctca aaaagctgtg tatgatcgaa tgcgagctga tcagaagaaa tttggtaaag catcatgggc agcggctgct gaacggatgg aaaaactcca gtatgcagtt tctaaggaaa ctttgcagat gatgagagct aaagagatat gcttggaaca gcggaaacat gcactaaagg aagagatgca gagtttgcgg ggtggtacag aagcgatagc acgattggat cagttagaag ctgattatta tgatctgcaa cttcagttgt atgaagtaca gtttgaaatc ttgaagtgtg aagagttact attgacagcg caactagaaa gcatcaaaag acttatatca gaaaaaagag atgaagtggt atactatgac acttacgaaa gcatggaggc catgctggag aaggaagaga tggcagcatc tgcgtactta cagagagaag agctgcagaa acttcagcag aaagcacgcc agctggaagc aagacgtgga cgggtttctg ccaagaaatc ctacctcaga aataaaaagg aaatatgtat tgcaaaacac aatgaaaaaa tccaacagcg cactcggatt gaagatgaat atagaaccca tcacacagta caactaaaga gagaaaaatt acatgatgaa gaagaaagaa aaagtgcctg ggttagccaa gagagacaga gaacactgga tagacttcga acatttaaac agaggtatcc tgggcaagtc atacttaaat caaccagatt acgactagct catgcaagaa gaaaaggtgc agcaagtcct gttctccaag aggatcattg tgactcttta ccaagtgtgt tacaggtaga agagaaaact gaagaggtgg gagaaggaag agtcaagcgt gggccatcac agacaacaga accccagagc cttgtgcaac ttgaagatac ttcattaaca caacttgaag ccacctcatt acctctcagt ggtgttacct ctgaactgcc tcctactata tctcttccac ttttgaataa caacctcgaa ccatgttctg ttaccataaa tccactccca tcccctcttc ctccaacacc accacctctg cctgttgcta aggacagtgg cccagagaca ctggagaaag atctgcctag aaaggagggg aatgagaaga ggatcccaaa gtcagccagt gccccctcag cacacctctt tgacagcagc cagctggtca gtgcacggaa gaagctcaga aagactgctg aaggtttgca gaggaggaga gtgagctcac ccatggatga ggtgctagcc tccttgaagc gtggtagttt tcatctgaaa aaggttgaac agcgaactct gcctcctttt cctgatgaag atgatagtaa taatatcttg gcacaaataa ggaaaggggt aaaattgaag aaggtacaga aggatgtttt gagagaatcc ttcacacttc tacccgatac agaccctcta acacggagca tccatgaagc tcttagaaga attaaagaag catccccaga gtcagaggac gaagaggagg ctttaccttg cacagactgg Protein function: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location. [The UniProt Consortium]