ITM2C (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 663 Sequence: atggtgaaga ttagcttcca gcccgccgtg gctggcatca agggcgacaa ggctgacaag gcgtcggcgt cggcccctgc gccggcctcg gccaccgaga tcctgctgac gccggctagg ctggcccgag ataacttctt ccgctgtggt gtgctgtatg aggactccct gtcctcccag gtccggactc agatggagct ggaagaggat gtgaaaatct acctcgacga gaactacgag cgcatcaacg tgcctgtgcc ccagtttggc ggcggtgacc ctgcagacat catccatgac ttccagcggg gtctgactgc gtaccatgat atctccctgg acaagtgcta tgtcatcgaa ctcaacacca ccattgtgct gccccctcgc aacttctggg agctcctcat gaacgtgaag agggggacct acctgccgca gacgtacatc atccaggagg agatggtggt cacggagcat gtcagtgaca aggaggccct ggggtccttc atctaccacc tgtgcaacgg gaaagacacc taccggctcc ggcgccgggc aacgcggagg cggatcaaca agcgtggggc caagaactgc aatgccatcc gccacttcga gaacaccttc gtggtggaga cgctcatctg cggggtggtg Protein function: Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation. [The UniProt Consortium]